Washing the Femoral Canal Results in More Predictable Seating of a Short, Tapered Femoral Stem.

Background: It is critical that a femoral rasp be effective in preparing the proximal femur to accept the size and the geometry of the femoral implant at the time of total hip arthroplasty. Short, tapered femoral stems may be at greater risk because they require the preparation of a short femoral region without any reaming. We undertook a study to determine the effect on implant seating in femora that were prepared by rasping alone with those that were rasped and the canal was washed with saline at the time of cementless THA with a short, tapered femoral implant.

Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2.

The biological activity of 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] remains controversial, but it has been suggested that it contributes to fracture healing. Cyp24a1-/- mice, synthesizing no 24R,25(OH)2D3, show suboptimal endochondral ossification during fracture repair, with smaller callus and reduced stiffness. These defects were corrected by 24R,25(OH)2D3 treatment, but not by 1,25-dihydroxyvitamin D3.

The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice.

BRIL (bone-restricted IFITM-like), is a short transmembrane protein expressed almost exclusively in osteoblasts. Although much is known about its bone-restricted gene expression pattern and protein biochemical and topological features, little information is available for BRIL physiological function. Two autosomal dominant forms of osteogenesis imperfecta (OI) are caused by distinct, but recurrent mutations in the BRIL gene.

CYP24A1-deficiency does not affect bone regeneration in distraction osteogenesis.

The putative biological activity of 24,25-(OH)D remains unclear. Previous studies showed an increase in the circulating levels of this metabolite following fracture in chicks. Our laboratory has generated a mouse model deficient for the Cyp24a1 gene for studying the role of 24,25-(OH)D.

Lack of circulating pigment epithelium-derived factor is a marker of osteogenesis imperfecta type VI.

Background: Osteogenesis imperfecta (OI) type VI is a rare autosomal recessive bone fragility disorder that is caused by inactivating mutations in SERPINF1, the gene that encodes pigment-epithelium derived factor (PEDF). Determining PEDF serum levels might facilitate the diagnosis of OI type VI.

Objective: The objective of the study was to assess whether lack of circulating PEDF is a specific marker of OI type VI and to evaluate whether PEDF serum levels are influenced by other metabolic bone diseases.

Serum 24,25-dihydroxyvitamin D concentrations in osteogenesis imperfecta: relationship to bone parameters.

Background: Several studies suggest that 24,25-dihydroxyvitamin D [24,25(OH)₂D] may have an effect on bone mass and metabolism.

Objective: We evaluated the relationship between serum 24,25(OH)₂D levels and bone density and bone metabolism in children with a primary bone disorder-osteogenesis imperfecta (OI).

Materials And Methods: The study included 132 patients (age, 1.