Introduction: Hydropic degeneration, sometimes reported as perinodular hydropic degeneration, is one of the various degenerative changes that can be observed in uterine leiomyomas. It can be a clinical and a histopathological diagnostic pitfall.
Case Report: Here we present the case of a 40-year-old woman with leiomyoma uteri with perinodular hydropic degeneration.