Publications by authors named "Abby Mutic"

Per- and polyfluoroalkyl substances (PFAS) constitute a large class of chemicals with widespread exposure in the United States. They are commonly used in products because they repel water, stain, and grease. Concerns about the health impacts from PFAS exposures continue to grow as science has linked this chemical family with a wide range of health effects.

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  • A study in Georgia investigated the link between extreme heat exposure during pregnancy and neural tube defects (NTDs) in babies, analyzing data from 1994-2017 involving 825 NTD cases and 3,300 control births.
  • Researchers measured extreme heat as days when temperatures exceeded the 95th percentile for each county during an eight-week period around conception.
  • Findings indicated increased risks of NTDs, particularly for spina bifida, with higher odds correlating with more consecutive days of extreme heat; this raises concerns about the health impacts of rising global temperatures on pregnant individuals.
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Background: Epidemiologic studies have revealed associations between traffic-related pollutants such as diesel particulate matter (PM) and asthma outcomes in children, but the inflammatory features associated with diesel PM exposure in children with asthma are not understood.

Objective: To evaluate symptoms, exacerbations, and lung function measures in children with uncontrolled asthma and their associations with residential proximity to major roadways and to determine associations between diesel PM exposure and systemic inflammatory cytokines, circulating markers of T-cell activation and exhaustion, and metabolomic features using biomarker studies.

Methods: Children 5 to 17 years of age with physician-diagnosed, uncontrolled asthma despite treatment with an asthma controller medication completed a research visit involving questionnaires, lung function testing, and venipuncture for biomarker studies.

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The purpose of this course innovation was to introduce Next Generation NCLEX (NGN)-style questions and create supplemental cooperative learning assignments (CLAs) to enhance content mastery in a prelicensure maternity course. The course itself is divided into three modules focusing on maternal, newborn, and women's health. Three CLAs and two Canvas quizzes were developed to reinforce the course content and integrate NGN-style case studies and questions.

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Background: Environmental justice mandates that no person suffers disproportionately from environmental exposures. The Environmental Justice Index (EJI) provides an estimate of the environmental burden for each census tract but has not yet been used in asthma populations.

Objective: We hypothesized that children from census tracts with high environmental injustice determined by the EJI would have a greater burden of asthma exacerbations, poorer asthma control, and poorer lung function over 12 months.

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Background: Inhaled air pollutants are environmental determinants of health with negative impacts on human health. Air pollution has been linked to the incidence and progression of disease, with its effects unequally distributed across the population. Children compared to adults are a highly vulnerable group and suffer disproportionately from systemic environmental inequities exacerbated by social determinants.

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  • The study examined how blood eosinophil counts in preschool children with recurrent wheezing could predict the risk of exacerbations and treatment responses.
  • The researchers merged data from three clinical trials involving 1,074 participants to analyze outcomes like exacerbation rates and hospitalization.
  • Results indicated that higher eosinophil counts were linked to increased exacerbation risk, and adding a second biomarker improved detection of outcomes and treatment effectiveness, despite the limited specificity of eosinophil counts.
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  • Social determinants of health affect asthma outcomes in school-age children, but research on these factors in preschool children with recurrent wheezing is limited.
  • The study hypothesized that preschoolers at higher risk of social vulnerability would experience more frequent symptoms and exacerbations, despite receiving consistent asthma care.
  • Results showed that these vulnerable preschoolers did not have more frequent infections, but experienced more severe symptoms during flare-ups and their caregivers reported poorer quality of life, highlighting the need for addressing social inequities to improve health outcomes.
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To examine the health status of Hispanic agricultural workers in Florida and Georgia. Health data from agricultural workers in the Farm Worker Family Health Program (June 2019) and research studies in Florida (May 2015 and May 2019) were examined. Data from 728 agricultural workers were collected through sociodemographic questionnaire and clinical data.

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Background: Obesity complicates the clinical manifestations of asthma in children. However, few studies have examined longitudinal outcomes or markers of systemic inflammation in obese asthmatic children.

Objective: We hypothesized that obese children with asthma would have: (1) poorer clinical outcomes over 12 months, (2) decreased responsiveness to systemic corticosteroid administration, (3) greater markers of systemic inflammation, and (4) unique amino acid metabolites associated with oxidative stress.

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Current indicators of anthropogenic climate change are foreboding and demand immediate collaborative action and policy change to reduce carbon emissions rapidly. Human and environmental effects of climate change are already widespread. Large-scale disruptive disasters and weather-related events have downstream and cascading effects on livelihoods, national economies, population health and global human rights.

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(1) Polybrominated diphenyl ethers (PBDEs) were widely produced in the United States until 2004 but remain highly persistent in the environment. The potential for PBDEs to disrupt normal neuroendocrine pathways resulting in depression and other neurological symptoms is largely understudied. This study examined whether PBDE exposure in pregnant women was associated with antenatal depressive symptomatology.

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Objectives: To analyze the predictors of health care utilization among respondents to the National Agricultural Worker Survey. Specifically, we hypothesized that English proficiency would predict utilization of health care services within the last 2 years.

Methods: Using the 2015-2016 National Agricultural Worker Survey, we performed a secondary data analysis to analyze the predictors of health care utilization within the last 2 years in the United States' agricultural worker population.

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Background: Girasoles is an academic-community partnership investigating heat-related illness (HRI) among farm-workers. An unexpected outcome is health screening and intervention for participants without access to health care.

Objectives: We present a case of renal failure in a farmworker, detected during data collection, to illustrate how academic-community collaboration can result in clinical benefits for study participants.

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Nursing care of the neonate in the neonatal intensive care unit (NICU) is complex, due in large part to various physiological challenges. A newer and less well-known physiological consideration is the neonatal microbiome, the community of microorganisms, both helpful and harmful, that inhabit the human body. The neonatal microbiome is influenced by the maternal microbiome, mode of infant birth, and various aspects of NICU care such as feeding choice and use of antibiotics.

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Biological and environmental changes to maternal and newborn microbiomes in the postnatal period can affect health outcomes for the mother-baby dyad. Postpartum sleep deprivation and unmet dietary needs can alter commensal bacteria within the body and disrupt gut-brain communication. Perineal injury and breast infections also change microbial community composition, potentiating an environment favoring pathogen growth.

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Background: Farmworkers working in hot and humid environments have an increased risk for heat-related illness (HRI) if their thermoregulatory capabilities are overwhelmed. The manifestation of heat-related symptoms can escalate into life-threatening events. Increasing ambient air temperatures resulting from climate change will only exacerbate HRI in vulnerable populations.

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Human exposure to endocrine disrupting chemicals (EDCs) has become common as a result of widespread application of these chemicals to the food supply, environmental contamination, and occupational exposures (Caserta et al., 2011). However, relatively little is known about the effects of EDCs such as ethylene thiourea (ETU) in developing fetuses and the lasting implications of this disruption on human development from birth through adulthood.

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  • The maternal microbiome plays a crucial role in pregnancy outcomes and the health of both mothers and infants, with ongoing research promising improvements in addressing complications and chronic health issues.
  • This study reviews the best practices for collecting and storing microbiome samples from mothers and children, highlighting the importance of considering medication, health, and hygiene factors before sampling.
  • Effective sampling methods are essential for generating reliable research results, and nurses are tasked with conducting this research and applying its findings in clinical settings, while also navigating ethical challenges related to vulnerable populations.
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Affordable measurement of core body temperature (T) in a continuous, real-time fashion is now possible. With this advance comes a new data analysis paradigm for occupational epidemiology. We characterize issues arising after obtaining T data over 188 workdays for 83 participating farmworkers, a population vulnerable to effects of rising temperatures due to climate change.

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