Publications by authors named "Abby Macbeth"

Background: It is not known whether alopecia areata (AA) is associated with a greater or reduced risk for infection.

Aim: We undertook a population-based study exploring associations between AA and common infections.

Methods: We extracted primary care records from the UK Oxford-Royal College of General Practitioners Research and Surveillance Centre database (trial registration: NCT04239521).

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Article Synopsis
  • Alopecia areata (AA) is associated with a higher prevalence of atopic and autoimmune conditions compared to healthy individuals, with 37.2% of people with AA experiencing atopic conditions and 11.5% experiencing autoimmune conditions.
  • In a study involving over 8,000 adults with newly diagnosed AA, those in the AA group were 43% more likely to develop atopic conditions and 45% more likely to develop autoimmune conditions than a matched control group.
  • Specific conditions like atopic dermatitis, allergic rhinitis, autoimmune hypothyroidism, systemic lupus erythematosus, and vitiligo showed significantly increased risks in the AA group, highlighting the complexity of immune responses involved in AA.
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Background: Alopecia areata (AA) is a common cause of nonscarring hair loss that can have a profound psychological impact.

Objectives: To assess the co-occurrence of depression and anxiety in adults with AA compared with the general population, and to evaluate the mental health treatment burden and impact on time off work and unemployment.

Methods: In total, 5435 people with newly diagnosed AA in UK primary care were identified from the Oxford Royal College of General Practitioners Research and Surveillance Centre network database, and matched to 21 740 controls.

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Introduction: Alopecia areata (AA) is a common cause of immune-mediated non-scarring hair loss. Links between AA and common mental health, autoimmune and atopic conditions, and common infections have previously been described but remain incompletely elucidated and contemporary descriptions of the epidemiology of AA in the UK are lacking.

Methods And Analysis: Retrospective study series using a large population-based cohort (5.

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Frontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively women. Despite a dramatic recent increase in incidence the aetiopathogenesis of FFA remains unknown. We undertake genome-wide association studies in females from a UK cohort, comprising 844 cases and 3,760 controls, a Spanish cohort of 172 cases and 385 controls, and perform statistical meta-analysis.

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Although most paediatric hair loss presenting to clinicians is due to alopecia areata, unusual patterns should prompt a careful history.

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We report a case of dermatitis herpetiformis co-localised with segmental vitiligo in a 37-year-old woman with a background history of autoimmune polyglandular syndrome type 2. We propose genetic mosaicism as a possible mechanism. There has only been one previous case report in which dermatitis hepetiformis co-localised in close proximity but not exclusively within vilitigo in a patient with autoimmune thyroiditis.

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Alopecia may indicate underlying systemic disease and is associated with significant impairment of quality of life. A thorough history and examination, including specialist techniques, can give vital clues to the aetiology. This article provides an overview of the common and important hair loss disorders for the busy clinician.

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