Objective: To review the current scientific literature concerning the implication of biomarkers collected from saliva in the diagnosis of temporomandibular disorders (TMD).
Methods: A comprehensive literature search was conducted on PubMed, Google Scholar, Embase, MEDLINE and Web of Science to gather articles published between 2012 and 2021. Based on the eligibility criteria, articles were reviewed in full and precise data was extracted.
The gut microbiota has been indicated to play a crucial role in health and disease. Apart from changes in composition between healthy individuals and those with a disease or disorder, it has become clear that also microbial activity is important for health. For instance, butyrate has been proven to be beneficial for health, because, amongst others, it is a substrate for the colonocytes, and modulates the host's immune system and metabolism.
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