Publications by authors named "Abbink E"
Article Synopsis
- Mitochondrial disease is a rare condition currently lacking approved treatments, with sonlicromanol being a promising candidate that modifies key metabolic and inflammatory pathways.
- A Phase 2b study was conducted to evaluate sonlicromanol's safety and efficacy in adults with a specific genetic mutation, involving both a randomized controlled trial (RCT) and a long-term extension study.
- While the primary endpoint of the RCT didn't show significant results, there were indications of improvement in certain cognitive and emotional assessments among patients who were more affected at baseline.
Article Synopsis
- The Hypo-METRICS study explored how continuous glucose monitoring (CGM) detects hypoglycemia and its relevance for people with type 1 and insulin-treated type 2 diabetes.
- Researchers tracked 276 type 1 and 321 type 2 diabetes participants using CGM for 10 weeks, correlating sensor-detected hypoglycemia (SDH) with person-reported hypoglycemia (PRH).
- Results indicated that a significant portion of CGM-detected hypoglycemia is asymptomatic, with 65% of low readings (under 70 mg/dL) not accompanied by symptoms and many reported symptoms occurring at higher glucose levels (over 70 mg/dL).
Article Synopsis
- The study aimed to explore how experiencing hypoglycemia affects daily life in adults with type 1 and insulin-treated type 2 diabetes using the Hypo-METRICS app over 70 days.
- Participants reported their hypoglycemia experiences through daily check-ins while wearing a glucose sensor that provided data without their knowledge.
- Results indicated that self-reported hypoglycemia negatively impacted energy, mood, cognitive function, and sleep quality, while sensor-detected hypoglycemia alone did not show these associations.
Article Synopsis
- The Hypo-METRICS app was developed to gather real-time data on the physical, psychological, and social effects of hypoglycaemia in adults with type 1 and insulin-treated type 2 diabetes, overcoming limitations of traditional retrospective reporting methods.
- Participants in the study wore continuous glucose monitors and provided daily assessments of their hypoglycaemia experiences and daily functioning over a 10-week period, achieving a high overall app completion rate of 91%.
- Factors such as older age, routine continuous glucose monitoring use, and greater time spent below critical glucose levels were positively linked to higher app engagement, suggesting the app is a valuable tool for diabetes research.
Purpose: The rising frequency of extreme heat events poses an escalating threat of heat-related illnesses and fatalities, placing an additional strain on global healthcare systems. Whether the risk of heat-related issues is sex specific, particularly among the elderly, remains uncertain.
Methods: 16 men and 15 women of similar age (69 ± 5 years) were exposed to an air temperature of 39.
Article Synopsis
- - The study explored how awareness of hypoglycemia affects the real-time symptoms reported by adults with insulin-treated type 1 (T1D) and type 2 diabetes (T2D) using a smartphone app called Hypo-METRICS.
- - Among the 531 participants, those with impaired awareness of hypoglycemia (IAH) were less likely to report certain symptoms compared to those with normal awareness, especially at lower glucose levels.
- - The findings suggest that the Hypo-METRICS app effectively captures differences in hypoglycemia symptoms based on awareness levels, making it a potentially valuable tool for both research and clinical practices.
Article Synopsis
- The study investigates whether the traditional measurement of nocturnal hypoglycemia (00:00-06:00) accurately captures hypoglycemic episodes in adults with type 1 (T1D) or insulin-treated type 2 diabetes (T2D) by comparing it to actual sleep patterns.
- Participants used continuous glucose monitors and activity trackers to record episodes of hypoglycemia over 10 weeks, revealing that rates of hypoglycemia during actual sleep were higher than those measured during the standard clock-based hours.
- The findings suggest that using a fixed overnight time frame may underestimate the incidence of hypoglycemia while asleep, and future research should incorporate sleep tracking technology for more accurate assessments.
Objectives: To systematically evaluate the performance of COVID-19 prognostic models and scores for mortality risk in older populations across three health-care settings: hospitals, primary care, and nursing homes.
Study Design And Setting: This retrospective external validation study included 14,092 older individuals of ≥70 years of age with a clinical or polymerase chain reaction-confirmed COVID-19 diagnosis from March 2020 to December 2020. The six validation cohorts include three hospital-based (CliniCo, COVID-OLD, COVID-PREDICT), two primary care-based (Julius General Practitioners Network/Academisch network huisartsgeneeskunde/Network of Academic general Practitioners, PHARMO), and one nursing home cohort (YSIS) in the Netherlands.
Background: The COVID-19 pandemic has a large impact worldwide and is known to particularly affect the older population. This paper outlines the protocol for external validation of prognostic models predicting mortality risk after presentation with COVID-19 in the older population. These prognostic models were originally developed in an adult population and will be validated in an older population (≥ 70 years of age) in three healthcare settings: the hospital setting, the primary care setting, and the nursing home setting.
View Article and Find Full Text PDFAims/hypothesis: It is generally recommended to reduce basal insulin doses after exercise to reduce the risk of post-exercise nocturnal hypoglycaemia. Based on its long t, it is unknown whether such adjustments are required or beneficial for insulin degludec.
Methods: The ADREM study (Adjustment of insulin Degludec to Reduce post-Exercise (nocturnal) hypoglycaeMia in people with diabetes) was a randomised controlled, crossover study in which we compared 40% dose reduction (D40), or postponement and 20% dose reduction (D20-P), with no dose adjustment (CON) in adults with type 1 diabetes at elevated risk of hypoglycaemia, who performed a 45 min aerobic exercise test in the afternoon.
Introduction: Hypoglycaemia is a significant burden to people living with diabetes and an impediment to achieving optimal glycaemic outcomes. The use of continuous glucose monitoring (CGM) has improved the capacity to assess duration and level of hypoglycaemia. The personal impact of sensor-detected hypoglycaemia (SDH) is unclear.
View Article and Find Full Text PDFThe size-weight illusion is well-known: if two equally heavy objects differ in size, the large one feels lighter than the small one. Most explanations for this illusion assume that because the information about the relevant attribute (weight itself) is unreliable, information about an irrelevant but correlated attribute (size) is used as well. If such reasoning is correct, one would expect that the illusion can be inverted: if size information is unreliable, weight information will be used to judge size.
View Article and Find Full Text PDFPhysical exercise has many health benefits, equally so for people with diabetes mellitus. The glycaemic responses to the various types of exercise differ and include an increased risk of late (nocturnal) hypoglycaemia, making physical exercise a challenge for some people with diabetes who are treated with insulin. Insulin treatment interferes with normal physiologic responses to exercise, which are necessary to maintain the blood glucose level within the normal range.
View Article and Find Full Text PDFBackground: To date, survival data on risk factors for COVID-19 mortality in western Europe is limited, and none of the published survival studies have used a competing risk approach. This study aims to identify risk factors for in-hospital mortality in COVID-19 patients in the Netherlands, considering recovery as a competing risk.
Methods: In this observational multicenter cohort study we included adults with PCR-confirmed SARS-CoV-2 infection that were admitted to one of five hospitals in the Netherlands (March to May 2020).
Objective: To describe clinical characteristics, disease course and outcomes in a large and well-documented cohort of hospitalized COVID-19 patients in the Netherlands.
Methods: We conducted a multicentre retrospective cohort study in The Netherlands including 952 of 1183 consecutively hospitalized patients that were admitted to participating hospitals between March 2nd, 2020, and May 22nd, 2020. Clinical characteristics and laboratory parameters upon admission and during hospitalization were collected until July 1st.
Introduction: Sex differences in cardiometabolic risk factors and their management in type 2 diabetes (T2D) have not been fully identified. Therefore, we aimed to examine differences in cardiometabolic risk factor levels, pharmacological treatment and achievement of risk factor control between women and men with T2D.
Research Design And Methods: Cross-sectional data from the Dutch Diabetes Pearl cohort were used (n=6637, 40% women).
Aim: To describe the prevalence and characteristics of polypharmacy in a Dutch cohort of individuals with type 2 diabetes.
Methods: We included people with type 2 diabetes from the Diabetes Pearl cohort, of whom 3886 were treated in primary care and 2873 in academic care (secondary/tertiary). With multivariable multinomial logistic regression analyses stratified for line of care, we assessed which sociodemographic, lifestyle and cardiometabolic characteristics were associated with moderate (5-9 medications) and severe polypharmacy (≥10 medications) compared with no polypharmacy (0-4 medications).
Background: Finding a suitable treatment for HCV patients with swallowing disorders is still a major challenge. In practice, direct-acting antivirals are crushed without knowledge of adequate absorption. Crushing can alter drug exposure, possibly leading to treatment failure, development of resistance or toxicity.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on the prevalence and factors influencing impaired awareness of hypoglycemia (IAH) and severe hypoglycemia among Dutch individuals with insulin-treated type 2 diabetes.
- Approximately 9.7% of participants experienced IAH, while over 31% reported severe hypoglycemic events, highlighting a significant concern among this population.
- Factors such as complex insulin regimens, ethnicity, and medication usage were associated with higher risks of IAH and severe hypoglycemia, indicating the need for tailored diabetes management strategies.
We aimed to evaluate the effect of the acid beverage Coca-Cola on the pharmacokinetics of velpatasvir (VEL) when given with omeprazole. This was an open-label, randomized, crossover trial in 11 healthy adults. A single dose of sofosbuvir/velpatasvir (SOF/VEL) 400/100 mg was administered alone (reference) or with omeprazole 40 mg once daily with water (intervention I); in the intervention II arm, omeprazole 40 mg was combined with 250 mL of Coca-Cola.
View Article and Find Full Text PDFBackground: Obesity is associated with low-grade inflammation that may be related to vascular disease. We hypothesized that inflammation in the subcutaneous adipose tissue is associated with impaired endothelium-dependent vasodilatation.
Methods: We assessed endothelial function by measuring forearm vascular response to acetylcholine and determined inflammation in subcutaneous fat biopsies in 2 groups of subjects; 15 patients with type 2 diabetes mellitus (T2DM) and 19 subjects with dyslipidaemia combined with hypertension (DcH).
Objective: Diabetes distress among patients from ethnic minorities is still poorly understood. We investigated the association between ethnicity and diabetes distress among ethnic minority groups of people with type 2 diabetes in the Netherlands, focusing on the possible effects of glycemic control, lifestyle factors, cardiovascular risk factors, and diabetes complications.
Research Design And Methods: Cross-sectional data from the Dutch Diabetes Pearl cohort included people with type 2 diabetes from primary, secondary, and tertiary diabetes care programs.
Aims: Individual indicators of socio-economic status have been associated with glycaemic control in people with Type 2 diabetes, but little is known about the association between partner's socio-economic status and HbA levels. We therefore examined the cross-sectional association between individual and partner's level of occupation on HbA levels in people with Type 2 diabetes in the Netherlands.
Methods: We included people with Type 2 diabetes with a partner who were treated in primary, secondary and tertiary care in the Diabetes Pearl cohort.