Individuals lack the ability to accurately detect emotional piloerection.

Piloerection (e.g., goosebumps) is an essential thermoregulatory and social signaling mechanism in non-human animals.

Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice.

The amyloid beta (Aβ) peptide is associated with the neurodegenerative and inflammatory changes in brains affected by Alzheimer's disease (AD). We hypothesized that the enteric nervous system also produces Aβ in an intestinal component of disease. To test this idea, we compared C57BL/6 wild-type (WT) male and female mice to two models of Alzheimer's disease, amyloid precursor protein (APP)/presenilin 1 (PS1) mice and amyloid precursor protein NL-G-F (App) mice, at 3, 6, and 12 months of age.

Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures.

Background: Increasing metabolism is a primary focus of many commercially available dietary supplements marketed to support weight management. Caffeine (e.g.

The effects of tournament preparation on anthropometric and sport-specific performance measures in youth judo athletes.

The purpose of this study was to characterize the adaptations imposed by 4 weeks of precompetition judo training in youth athletes. It was hypothesized that anthropometric and sport-specific performance would improve during the preparation for a junior national championship event. Twenty youth athletes (mean ± SD; chronological age: 13.

An alternative approach to the Army Physical Fitness Test two-mile run using critical velocity and isoperformance curves.

The purpose of this study was to evaluate the use of critical velocity (CV) and isoperformance curves as an alternative to the Army Physical Fitness Test (APFT) two-mile running test. Seventy-eight men and women (mean +/- SE; age: 22.1 +/- 0.

Predicting maximal aerobic capacity (VO2max) from the critical velocity test in female collegiate rowers.

The objective of this study was to examine the relationship between the critical velocity (CV) test and maximal oxygen consumption (VO2max) and develop a regression equation to predict VO2max based on the CV test in female collegiate rowers. Thirty-five female (mean ± SD; age, 19.38 ± 1.

Impact of testing strategy on expression of upper-body work capacity and one-repetition maximum prediction after resistance training in college-aged men and women.

The purpose of this study was to assess the effect of resistance training on upper-body muscular strength and the expression of work capacity and muscular endurance. In addition, a training-induced change in the relationship between muscular strength and endurance was assessed by testing changes in the accuracy of using endurance repetitions to predict 1 repetition maximum (1RM) bench press before and after training. College-aged men (n = 85) and women (n = 62) completed a 12-week linear periodization resistance training program.

The reliability of the intermittent critical velocity test and assessment of critical rest interval in men and women.

The purpose of this study was to examine the reliability of the intermittent critical velocity (ICV) test and assess critical rest interval (CRI) during repeated-sprint exercise. The ICV test is used to examine the linear relationship between total distance and time-to-exhaustion during interval exercise, yielding a repeatable, moderate-intensity parameter (ICV), a high-intensity exhaustive parameter (W'), and CRI. CRI is the theoretical rest period needed to complete a series of repeated bouts of exercise without fatigue.

Critical velocity: a predictor of 2000-m rowing ergometer performance in NCAA D1 female collegiate rowers.

The aims of this study were to examine the use of the critical velocity test as a means of predicting 2000-m rowing ergometer performance in female collegiate rowers, and to study the relationship of selected physiological variables on performance times. Thirty-five female collegiate rowers (mean ± s: age 19.3 ± 1.

International Society of Sports Nutrition position stand: meal frequency.

Position Statement: Admittedly, research to date examining the physiological effects of meal frequency in humans is somewhat limited. More specifically, data that has specifically examined the impact of meal frequency on body composition, training adaptations, and performance in physically active individuals and athletes is scant. Until more research is available in the physically active and athletic populations, definitive conclusions cannot be made.

The determination of critical rest interval from the intermittent critical velocity test in club-level collegiate hockey and rugby players.

The intermittent critical velocity (ICV) test is used to quantify the relationship between velocity and time to exhaustion, yielding an aerobic parameter (ICV), an anaerobic parameter (anaerobic running capacity [ARC]), and critical rest interval (CRI). Critical rest interval is the theoretical rest period needed to maintain repeated bouts of exercise for an extended period of time without inducing fatigue during intermittent treadmill running. Fourteen collegiate, club-level male participants (mean ± SD; age: 21.

Determination of aerobic and anaerobic performance: a methodological consideration.

This study was designed to compare critical velocity (CV) and anaerobic running capacity (ARC) estimates using the criterion method of four runs with two and three combination bouts to reduce the time and energy demands of the subjects. Twenty-eight men and women (mean ± SD; age = 21.9 ± 3.

The role of histone H4 biotinylation in the structure of nucleosomes.

Background: Post-translational modifications of histones play important roles in regulating nucleosome structure and gene transcription. It has been shown that biotinylation of histone H4 at lysine-12 in histone H4 (K12Bio-H4) is associated with repression of a number of genes. We hypothesized that biotinylation modifies the physical structure of nucleosomes, and that biotin-induced conformational changes contribute to gene silencing associated with histone biotinylation.

Mechanical scale and load cell underwater weighing: a comparison of simultaneous measurements and the reliability of methods.

Both load cell and mechanical scale-based hydrostatic weighing (HW) systems are used for the measurement of underwater weight. However, there has been no direct comparison of the 2 methods. The purpose of the current investigation was to simultaneously compare a load cell and mechanical scale for use in HW.

The development of physiological profiles and identification of training needs in NCAA female collegiate rowers using isoperformance curves.

The purpose of this study was to propose a systematic method for the identification of training strategies and team selection using isoperformance curves. Rowing is a sport that relies on both aerobic and anaerobic energy contributions during a standard 2,000 m competition. The critical velocity model combines both aerobic (critical velocity, CV) and anaerobic (anaerobic rowing capacity, ARC) parameters in a single two-dimensional graphic display.

Physiological effects of caffeine, epigallocatechin-3-gallate, and exercise in overweight and obese women.

The aim of this study was to evaluate the combined effects of a 10-week exercise program with ingestion of caffeine and epigallocatechin-3-gallate (EGCG) on body composition, cardiovascular fitness, and strength in overweight and obese women. In a double-blind, placebo-controlled approach, overweight and obese women (n = 27) were randomly assigned to treatment groups with exercise (an active-supplementing group with exercise (EX-Act) and a placebo group with exercise (EX-PL)) or without exercise (an active-supplementing group without exercise (NEX-Act) and a placebo group without exercise (NEX-PL)). All participants consumed 1 drink per day for 10 weeks; EX-Act and EX-PL participated in a concurrent endurance and resistance training program.

The possible combinatory effects of acute consumption of caffeine, creatine, and amino acids on the improvement of anaerobic running performance in humans.

Preexercise nutritional investigations have recently become a popular avenue of examining the interaction of multiple ingredients on exercise and training methods. The critical velocity (CV) test is used to quantify the relationship between total running distance and time to exhaustion (TTE), yielding aerobic (CV) and anaerobic parameters (anaerobic running capacity [ARC]). The purpose of this study was to examine the hypothesis that a preexercise supplement containing caffeine, creatine, and amino acids (Game Time; Corr-Jen Laboratories Inc, Aurora, CO) would positively impact CV and ARC in college-aged men and women.

Upper-body strength gains from different modes of resistance training in women who are underweight and women who are obese.

The purpose of this study was to determine the degree of upper-body strength gained by college women who are underweight and those who are obese using different modes of resistance training. Women who were underweight (UWW, n = 93, weight = 49.3 ± 4.

Reproducibility and validity of bioimpedance spectroscopy for tracking changes in total body water: implications for repeated measurements.

Bioimpedance spectroscopy (BIS) has been used to track changes in total body water (TBW). Accurate TBW estimations can be influenced by both methodological and biological factors. One methodological variation that contributes to BIS TBW errors is the electrode placement.

The effects of creatine loading and gender on anaerobic running capacity.

Creatine (Cr) loading consists of short-term, high-dosage Cr supplementation and has been shown to increase intramuscular total Cr content. Increases in body weight (BW) have been shown to result from Cr loading, with differences by gender, and increased BW may impact weight-bearing exercise. The critical velocity (CV) test is used to quantify the relationship between total running distance and time to exhaustion.

Role of beta-alanine supplementation on muscle carnosine and exercise performance.

In this narrative review, we present and discuss the current knowledge available on carnosine and beta-alanine metabolism as well as the effects of beta-alanine supplementation on exercise performance. Intramuscular acidosis has been attributed to be one of the main causes of fatigue during intense exercise. Carnosine has been shown to play a significant role in muscle pH regulation.

Six weeks of high-intensity interval training with and without beta-alanine supplementation for improving cardiovascular fitness in women.

The purpose of the present study was to evaluate the effects of cycle ergometry high-intensity interval training (HIIT) with and without beta-alanine supplementation on maximal oxygen consumption rate (VO2 peak), cycle ergometer workload at the ventilatory threshold (VT W), and body composition. Forty-four women (mean +/- SD age = 21.8 +/- 3.

International society of sports nutrition position stand: caffeine and performance.

Position Statement: The position of The Society regarding caffeine supplementation and sport performance is summarized by the following seven points: 1.) Caffeine is effective for enhancing sport performance in trained athletes when consumed in low-to-moderate dosages (~3-6 mg/kg) and overall does not result in further enhancement in performance when consumed in higher dosages (>/= 9 mg/kg). 2.

The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance.

Background: A randomized, single-blinded, placebo-controlled, parallel design study was used to examine the effects of a pre-workout supplement combined with three weeks of high-intensity interval training (HIIT) on aerobic and anaerobic running performance, training volume, and body composition.

Methods: Twenty-four moderately-trained recreational athletes (mean +/- SD age = 21.1 +/- 1.