Plasma ammonia concentration after L-asparaginase therapy in 27 dogs with high-grade lymphoma or leukemia.

Objectives: To establish the occurrence of increased plasma ammonia concentration after L-asparaginase (L-asp) administration in dogs with high-grade lymphoma or leukemia; to identify risk factors for the development of hyperammonemia after L-asp administration; and to determine occurrence of adverse events related to hyperammonemia.

Design: Prospective case controlled study of sequentially enrolled dogs between May 2011 and March 2012.

Setting: A university veterinary teaching hospital.

Macrocytosis secondary to hydroxyurea therapy.

A 10-year-old, male neutered Shetland Sheepdog was presented to the University of Florida for evaluation of a well-granulated mast cell tumor. Hydroxyurea therapy was instituted and serial CBCs showed persistent mild anemia and macrocytosis without a corresponding increase in polychromasia. The dog's MCV increased progressively, reaching its highest value of 100.

The effect of marker location variability on noninvasive canine stifle kinematics.

Objective: Evaluate the effect of marker placement on kinematics of the canine stifle in 3 distinct hindlimb models.

Study Design: In vivo biomechanical study.

Animals: Normal adult mixed-breed dogs (n=5).

Comparison of canine stifle kinematic data collected with three different targeting models.

Objective: To model the kinematics of the canine stifle in 3 dimensions using the Joint Coordinate System (JCS) and compare the JCS method with linear and segmental models.

Study Design: In vivo biomechanical study.

Animals: Normal adult mixed breed dogs (n=6).

Effects of firocoxib, meloxicam, and tepoxalin on prostanoid and leukotriene production by duodenal mucosa and other tissues of osteoarthritic dogs.

Objective: To evaluate the in vivo effects of firocoxib, meloxicam, and tepoxalin on prostaglandin (PG) and leukotriene production in duodenal mucosa and other target tissues in dogs with chronic osteoarthritis (OA).

Animals: 8 dogs with chronic, unilateral OA of the stifle joint.

Procedures: In a crossover design, each dog received placebo (no treatment), firocoxib, meloxicam, or tepoxalin for 7 days, followed by a 21-day washout period.

Kinetic gait and subjective analysis of the effects of a tachykinin receptor antagonist in dogs with sodium urate-induced synovitis.

Objective: To examine the ability of preemptive administration of a proprietary neurokinin-1 (NK(1)) receptor antagonist to attenuate limb dysfunction associated with monosodium urate-induced synovitis in the stifle joints of dogs.

Animals: 16 clinically normal adult mixed-breed dogs (8 males and 8 females).

Procedures: A crossover study was conducted in 2 phases.