Publications by authors named "Abbey N Warren"
Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the cofactor and Interferon antagonist VP35. We previously showed that the covalent ubiquitination of VP35 promotes virus replication by regulating interactions with the polymerase complex.
View Article and Find Full Text PDFEbolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the co-factor and Interferon antagonist VP35. We previously showed that the covalent ubiquitination of VP35 promotes virus replication by regulating interactions with the polymerase complex.
View Article and Find Full Text PDFEbola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35's engagement in different functions are not well-understood. We previously showed that the host E3 ubiquitin ligase TRIM6 ubiquitinates VP35 at lysine 309 (K309) to facilitate virus replication.
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- - Type I interferons (IFN-I) play a crucial role in the body's antiviral immune response, and unanchored polyubiquitin (poly-Ub) is known to influence this process, although few interacting proteins have been identified.
- - Researchers developed a method to isolate unanchored poly-Ub from lung tissue and discovered that the RNA helicase DHX16 acts as a potential pattern recognition receptor (PRR) essential for enhancing IFN-I responses to viruses like influenza, Zika, and SARS-CoV-2.
- - silencing DHX16 reduced IFN-I production, which depends on the cooperation with RIG-I and unanchored K48-poly-Ub produced by the E3-U
Epigenetics, a rapidly emerging biological science, investigates changes in gene expression without any change to the primary DNA sequence. Epigenetics plays an important role in diverse areas, including nutritional sciences, psychology, and environmental sciences. In addition, epigenetic phenomena are closely implicated in various diseases, including cancer and neurological disorders.
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