Leveraging Explainable AI for Early Risk Prediction and Type Classification for Leukemia: Insights using Clinical Data from Pakistan.

Leukemia, a prevalent childhood cancer affecting the blood and bone marrow, necessitates a proactive approach to risk mitigation through lifestyle adaptations. Despite previous investigations into similar aspects across different cancer types, a comprehensive inquiry focusing on all leukemia subtypes within Pakistan remains a significant research gap. Acknowledging the influence of regional variations on individuals' lifestyles, this study aims to identify lifestyle and demographic factors associated with leukemia development and predict specific leukemia subtypes using clinical data.

Association between Socioeconomic Inequality and the Burden of Colon and Rectum Cancer in Asia: GLOBOCAN Sources and Methods.

Introduction: Colon cancer is the third most common malignancy worldwide, which is increasing in middle-income countries. Our aim in this study was to investigate the association between socioeconomic inequality and the burden of Colon and rectum cancer in Asia.

Methods: All accessible data sources from 1990 to 2019 Global Burden of Disease study were used to estimate the prevalence, mortality, and disability-adjusted life years and the burden of Colon and rectum cancer in Asia.

Recurrent Missense Driver STAT5B N642H Mutation in Children Transiting into Adolescence, with Acute Lymphoid Leukemia and its In silico Inhibition.

Background: The occurrence of gain of function mutations in STAT5B has been associated to survival, and drug resistance in Leukemia. In silico screening of compounds having inhibitory potential towards mutated proteins, can be helpful in the development of specific inhibitors.

Objective: This study was designed to screen selected JAK-STAT mutations in leukemia patients and virtual exploration of molecular interaction of potential inhibitors with their mutated products.

Serosurvey of Toxocariasis and Its Association With Allergic Asthma in Children: A Case-Control Study in Southwest Iran.

Evidence from multiple data sources indicates that toxocariasis might play a role in the allergic asthma in children. This case-control study investigated the connection between Toxocara seropositivity and allergic asthma. It also sought to identify the conventional risk factors associated with both asthma and Toxocara infection.

A Bibliometric Analysis on Urticaria: Roles of Oxidative Stress, Inflammation, Immunity, and Treatment Modalities.

This study provides a comprehensive bibliometric analysis of global research on urticaria, aiming to chart its progression, assess its relevance, and explore the roles of oxidative stress, inflammation, and immunity in its pathogenesis. Additionally, by analyzing data from PubMed and Scopus, we mapped research trends, identified leading authors and institutions, and examined global collaboration patterns. We also evaluated the impact of oxidative stress, inflammation, and immunity on urticaria and assessed the roles of both conventional and traditional medicine in its management.

Comparative study of nanohydroxyapatite-emdogain effects on apical papilla stem cell survival and differentiation.

Background: The study was designed to explore the enhanced impact of nano-hydroxyapatite and emdogain on the survival and osteogenic/odontogenic differentiation of human stem cells isolated from the apical papilla (hSCAPs).

Materials And Methods: In this in vitro trial, hSCAPS obtained from intact impacted immature third molars were confirmed to have characteristic cell surface markers, then exposed to nanohydroxyapatite, emdogain, and nanohydroxyapatite coated with emdogain for durations of 1-3 days. The survival of apical papilla stem cells was measured using a methyl thiazolyl tetrazolium assay.

The Mental Health Traumas of Infertility: Impact and Consequences.

Stress is defined as "a state of mental and emotional tension resulting from adverse circumstances." The desire to be a parent is a primordial urge. Many individuals are unable to attain this goal and suffer from guilt, helplessness, and depression.

The Effect of Coenzyme Q10 on Tinnitus Severity and Sleep Quality in Patients with Presbycusis.

Introduction: Tinnitus is one of the symptoms of presbycusis that affects patients' sleep and social life. This study aimed to determine the effect of coenzyme Q10 (CoQ10) on treating tinnitus due to presbycusis.

Materials And Methods: In this double-blind, randomized clinical trial, 50 patients with tinnitus due to presbycusis were randomly divided into groups A and B, with 25 patients in each group.

Comparative Evaluation of Canal Transport and Centralization Between ProTaper Next and XP-endo Shaper Systems Using CBCT Analysis: An In Vitro Study.

This study compared the apical transportation and centering ratio of ProTaper Next (PTN) and XP-endo Shaper (XPS) nickel titanium (NiTi) rotary files in curved root canals using cone beam computed tomography (CBCT). The current in vitro study involved the mesiobuccal canals of mesial roots in 44 extracted mandibular first molars that exhibited apical curvature ranging from 10° to 30°. Two experimental groups were randomly formed from the teeth ( = 22) and subjected to instrumentation with PTN and XPS.

Morphological Features Influence the Drug Loading and Delivery Efficacy of Photoactivatable Gold Nanocarriers for Antitumor Photo/Chemotherapy.

Photoactivatable gold nanocarriers are transforming antitumor therapies by leveraging their distinctive physicochemical properties, enabling targeted drug delivery and enhanced therapeutic efficacy in cancer treatment. This study systematically investigates how surface topography and morphology of gold nanocarriers influence drug loading capacity, light-to-heat conversion efficiency, and overall therapeutic performance in photo/chemotherapy. We synthesized four distinct morphologies of gold nanoparticles: porous gold nanocups (PAuNCs), porous gold nanospheres (PAuNSs), solid gold nanocups (SAuNCs), and solid gold nanospheres (SAuNSs).

Recent advances in the application of engineered exosomes from mesenchymal stem cells for regenerative medicine.

Exosomes, cell-derived vesicles produced by cells, are fascinating and drawing growing interest in biomedical exploration due to their exceptional properties. There is intriguing evidence that exosomes are involved in major biological processes, including diseases and regeneration. Exosomes from mesenchymal stem cells (MSCs) have shown promising outcomes in regenerative medicine.

Predicting the victims of hate speech on microblogging platforms.

Hate speech constitutes a major problem on microblogging platforms, with automatic detection being a growing research area. Most existing works focus on analyzing the content of social media posts. Our study shifts focus to predicting which users are likely to become targets of hate speech.

The role of Internet of Things (IoT) technology in modern cultivation for the implementation of greenhouses.

In recent years, the Internet of Things (IoT) has become one of the most familiar names creating a benchmark and scaling new heights. IoT an indeed future of the communication that has transformed the objects (things) of the real world into smarter devices. With the advent of IoT technology, this decade is witnessing a transformation from traditional agriculture approaches to the most advanced ones.

Latest advancements and prospects in the next-generation of Internet of Things technologies.

The Internet of Things (IoT) is a sophisticated network of objects embedded with electronic systems that enable devices to collect and exchange data. IoT is a recent trending leading technology and changing the way we live. However, it has several challenges especially efficiency, architecture, complexity, and network topology.

A heuristic evaluation of a pharmacy surveillance information system.

Introduction: The pharmacy surveillance information system (PSIS) is intended to manage the dispensing practice of under-controlled drugs and substances. We designed and developed a PSIS for the first time in a developing country. This study aimed to evaluate the usability of this system using a heuristic evaluation method before the pilot implementation in outpatient pharmacies.

Liposomal Bupivacaine Versus Plain Bupivacaine for Pain Control Following Congenital Cardiac Surgery.

Background: Pain control following cardiac surgery can be challenging, and inadequate pain control is associated with postoperative complications. Liposomal bupivacaine can improve postoperative pain control due to its prolonged duration compared with plain bupivacaine. However, there is a paucity of data regarding its efficacy in congenital cardiac surgery.

The Association between Dental Caries, Periodontal Status, and Sleep Patterns in Children.

Aim And Background: Sleep quality has a significant impact on children's overall health and is associated with oral diseases. This study aimed to investigate the relationship between dental caries, periodontal status, and sleep patterns in 8-12-year-old children.

Materials And Methods: This cross-sectional study was conducted on 120 children aged 8-12 years.

Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors.

Optical biosensors have emerged as a powerful tool in analytical biochemistry, offering high sensitivity and specificity in the detection of various biomolecules. This article explores the advancements in the integration of optical biosensors with microfluidic technologies, creating lab-on-a-chip (LOC) platforms that enable rapid, efficient, and miniaturized analysis at the point of need. These LOC platforms leverage optical phenomena such as chemiluminescence and electrochemiluminescence to achieve real-time detection and quantification of analytes, making them ideal for applications in medical diagnostics, environmental monitoring, and food safety.

A hierarchical deep learning approach for diagnosing impacted canine-induced root resorption via cone-beam computed tomography.

Objectives: Canine-induced root resorption (CIRR) is caused by impacted canines and CBCT images have shown to be more accurate in diagnosing CIRR than panoramic and periapical radiographs with the reported AUCs being 0.95, 0.49, and 0.

Wing vein abnormality analysis in honeybee (Apis mellifera L. 1758) populations from Iran.

The insect wing is one of the most important characteristics that allowed insects to occupy most of the habitats on the planet. Honeybee wings has been the subject of studies on the venation abnormalities. A total of 424 honeybees from 14 locations were collected and all four wings were removed and examined for 19 abnormalities on the forewings and 6 abnormalities on the hindwings.

Isotropy of Cosmic Rays beyond 10^{20} eV Favors Their Heavy Mass Composition.

We report an estimation of the injected mass composition of ultrahigh energy cosmic rays (UHECRs) at energies higher than 10 EeV. The composition is inferred from an energy-dependent sky distribution of UHECR events observed by the Telescope Array surface detector by comparing it to the Large Scale Structure of the local Universe. In the case of negligible extragalactic magnetic fields (EGMFs), the results are consistent with a relatively heavy injected composition at E∼10  EeV that becomes lighter up to E∼100  EeV, while the composition at E>100  EeV is very heavy.

Unifying aspect-based sentiment analysis BERT and multi-layered graph convolutional networks for comprehensive sentiment dissection.

Aspect-Based Sentiment Analysis (ABSA) represents a fine-grained approach to sentiment analysis, aiming to pinpoint and evaluate sentiments associated with specific aspects within a text. ABSA encompasses a set of sub-tasks that together facilitate a detailed understanding of the multifaceted sentiment expressions. These tasks include aspect and opinion terms extraction (ATE and OTE), classification of sentiment at the aspect level (ALSC), the coupling of aspect and opinion terms extraction (AOE and AOPE), and the challenging integration of these elements into sentiment triplets (ASTE).