Quantitative comparison of pre-therapy Tc-macroaggregated albumin SPECT/CT and post-therapy PET/MR studies of patients who have received intra-arterial radioembolization therapy with Y microspheres.

Objective: The aim of our study was to compare yttrium -90 (Y) dosimetry obtained from pre-therapy Tc-macroaggregated albumin (MAA) SPECT/CT versus post-therapy PET/MRI imaging among patients with primary or metastatic hepatic tumors.

Materials And Methods: Prior to Y radioembolization (RE), 32 patients underwent a scan using MAA mimicking Y distribution. After RE with Y microspheres, the patients were imaged on a PET/MRI system.

Comparison of PET/CT and PET/MR imaging and dosimetry of yttrium-90 (Y) in patients with unresectable hepatic tumors who have received intra-arterial radioembolization therapy with Y microspheres.

Background: The aim of our study was to compare Y dosimetry obtained from PET/MRI versus PET/CT post-therapy imaging among patients with primary or metastatic hepatic tumors. First, a water-filled Jaszczak phantom containing fillable sphere with Y-chloride was acquired on both the PET/CT and PET/MRI systems, in order to check the cross-calibration of the modalities. Following selective internal radiation therapy (SIRT) with Y microspheres, 32 patients were imaged on a PET/CT system, immediately followed by a PET/MRI study.

Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.

In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers increased risk for neurodevelopmental disorders, cardiovascular disease, and cancers in adulthood. We examined associations between prenatal maternal stress and PTB, evaluating the role of DNA methylation at imprint regulatory regions. We enrolled women from prenatal clinics in Durham, NC.

Albinism and disease causing pathogens in Tanzania: are alleles that are associated with OCA2 being maintained by balancing selection?

Oculocutaneous albinism type 2 (OCA2) is present at significantly higher frequencies in sub-Saharan African populations compared to populations in other regions of the world. In Tanzania and other sub-Saharan countries, most OCA2 is associated with a common 2.7kb deletion allele.