Publications by authors named "Abbas Tafakhori"

Mirror aneurysms are rare and pose therapeutic challenges, with both endovascular and microsurgical options available. Single-stage and two-stage procedures are employed, but the optimal strategy remains unclear. This systematic review and meta-analysis evaluate the efficacy and safety of different therapeutic strategies for managing mirror aneurysms.

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Background: Pyridoxamine 5'-phosphate oxidase deficiency is a rare inborn error of vitamin B metabolism that presents with drug-resistant epileptic seizures. However, the condition is responsive to supplementation with the active vitamin B metabolite pyridoxal 5'-phosphate and, in some cases, pyridoxine.

Case Presentation: In this case report, a 10-year-old Iranian male of Fars ethnicity came to a regional hospital in Tehran, Iran with a chief complaint of tic-like movement.

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  • COVID-19 has been linked to an increase in mucormycosis and subsequently septic cavernous sinus thrombosis, prompting a study on the effects of anticoagulation (AC) in patients with COVID-related complications.
  • In this retrospective study involving 29 patients, researchers compared health outcomes, including mortality and neurological sequelae, between those who received AC and those who did not.
  • The findings indicated no significant differences in recovery or mortality rates between AC receivers and non-receivers, but due to the small sample size, the results remain inconclusive regarding the effectiveness of AC in this context.*
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Background: Patients who have Parkinson's disease (PD) present several non-motor issues, such as sexual dysfunction. Deep brain stimulation (DBS) is a great treatment for PD and could affect both motor and non-motor symptoms of patients.

Aim: The main goal of the current study is to evaluate the impact of DBS on the sexual dysfunction among patients with PD.

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  • Migraine affects 10% of the global population and is a major cause of disability, with myofascial trigger points (MTrPs) linked to both migraines and psychological issues like anxiety and depression.
  • A study with 68 migraine patients aimed to explore the relationship between MTrPs, migraine-related disability, anxiety, and depression by utilizing standard scales for assessments.
  • Results revealed a positive correlation between the number of MTrPs and headache severity, and patients with higher anxiety levels had more MTrPs, suggesting that addressing both physical and mental health issues could lead to better migraine treatment approaches.
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Objectives: The bio-distribution of Tc-99m HMPAO labeled platelets (LP), which could be used to image subtle thrombosis, is not reported in a human yet, which is the subject of the current study.

Method: The platelets were extracted from 49 ml whole blood and labeled with Tc-99m HMPAO, then re-injected to the healthy volunteer. Anterior and posterior whole body imaging was done by a dual-head gamma camera 3, 18, 33, 46, 81, 124, 190 min and 15 hours after injection.

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Background: Plectinopathy-associated disorders are caused by mutations in the gene encoding Plectin protein. mutations cause a spectrum of diseases defined by varying degrees of signs, mostly with epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) and plectinopathy-related disorder is limb-girdle muscular dystrophy type 2Q (LGMD2Q). Here we report three cases with EBS-MD and LGMD2Q disorders analyzed by exome sequencing followed by mutation confirmation.

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The Ketogenic Diet (KD) is a dietary regimen that is low in carbohydrates, high in fats, and contains adequate protein. It is designed to mimic the metabolic state of fasting. This diet triggers the production of ketone bodies through a process known as ketosis.

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Background: Migraine is a headache disorder that affects public health and reduces the patient's quality of life. Preventive medication is necessary to prevent acute attacks and medication overuse headaches (MOH). Agomelatine is a melatonin antagonist.

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  • The study aimed to compare the effects of a combination of atomoxetine and trazodone (A-T) against a placebo in patients with obstructive sleep apnea (OSA).
  • Conducted as a randomized, double-blind trial, 18 adults with OSA were treated on separate nights with the A-T combination and a placebo, with results measured through polysomnography.
  • The results showed that the A-T combination significantly reduced apnea-hypopnea index, improved REM sleep duration, and decreased number of apneas compared to the placebo, suggesting it may be an effective alternative treatment for patients who struggle with standard therapies for OSA.*
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Background: Treatment-resistant epileptic seizures are associated with reduced quality of life (QoL). As polypharmacy with routine antiseizure medications has many side effects, novel add-on treatments are necessary. Recent research showed the efficacy of add-on therapy by cannabidiol (CBD) on refractory epilepsy.

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Objectives: The prevalence of coronary artery disease (CAD) is high in patients with epilepsy using antiepileptic drugs (AED). Epilepsy, AED, or the type and duration of AED use , may contribute to higher CAD risk.In this study, myocardial perfusion imaging (MPI) was compared between patients using carbamazepine and valproate.

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