Balancing anticancer therapy efficacy and safety in advanced hepatocellular carcinoma: a case report.

Background: Hepatocellular carcinoma (HCC) is a significant health problem associated with several risk factors, increasingly driven by non-alcoholic steatohepatitis and metabolic syndrome. This association poses a challenge for the primary treatments of HCC, which may include immune checkpoint inhibitors and vascular endothelial growth factor inhibitors, due to their potential cardiotoxic effect. Therefore, it is imperative to balance the therapeutic effects of these agents with their potential cardiovascular adverse events.

Recent Breakthroughs in PET-CT Multimodality Imaging: Innovations and Clinical Impact.

This review presents a detailed examination of the most recent advancements in positron emission tomography-computed tomography (PET-CT) multimodal imaging over the past five years. The fusion of PET and CT technologies has revolutionized medical imaging, offering unprecedented insights into both anatomical structure and functional processes. The analysis delves into key technological innovations, including advancements in image reconstruction, data-driven gating, and time-of-flight capabilities, highlighting their impact on enhancing diagnostic accuracy and clinical outcomes.

Predictors of renal outcomes and mortality in patients with renal vein thrombosis: a retrospective multicenter study.

Background: Studies on renal vein thrombosis have been conducted as case reports or case series. The renal outcomes and mortality risk of renal vein thrombosis have not been fully established. We aimed to investigate the clinical characteristics, treatment modalities, and predictors of renal outcomes and mortality in patients with renal vein thrombosis in a large multicenter cohort.

SAFE ZONE OF JOINT LINE ELEVATION FOR THE TREATMENT OF KNEE FLEXION CONTRACTURE PREVENTING MID-FLEXION INSTABILITY IN TOTAL KNEE REPLACEMENT.

Background: In osteoarthritic knee, flexion deformity is caused by synovial inflammation, posterior femoral and tibial osteophytes tenting onto the capsule, ligamentous contracture and hamstring shortening. This study aimed to evaluate the safe zone of joint line elevation for the treatment of flexion knee contracture preventing mid-flexion instability in total knee replacement.

Methods: 51 knees with varus osteoarthritis undergoing TKA were evaluated.

Validity and Reliability of the Transcultural Arabic Adaptation of the Food-Mood Questionnaire Among College Students.

A culturally adapted screening tool for mental health and dietary quality is needed to address the significant challenges in mental health and suboptimal diets among college students. The purpose of this study was to validate the Food-Mood Questionnaire (FMQ), originally developed in English, among Arab college students. Students attending the University of Sharjah were invited to complete the questionnaire ( = 224).

An Atypical Case of Pancreatic Cancer with Mesenchymal Differentiation in a Patient with Primary Lung Adenocarcinoma: Insights into Tumor Biology and Novel Therapeutic Pathways.

: Pancreatic cancer is among the malignancies with the poorest prognosis, largely due to its aggressive nature and resistance to conventional therapies. : This report describes the case of a 69-year-old male patient with stage IV primary lung adenocarcinoma presenting with high levels of programmed death-ligand 1 (PD-L1). Simultaneously, abdominal computed tomography (CT) showed a dilated pancreatic duct at the level of the pancreatic head and a hypodense lesion in the uncinate process involving the superior mesenteric artery.

Extracellular lipase production from Bacillus cereus by using agro-industrial waste.

Lipases are crucial biocatalysts in various industrial applications, and there is considerable interest in developing sustainable methods for their synthesis. This study focuses on the isolation, screening, and comparison of Bacillus cereus strains to produce extracellular lipases utilizing agro-industrial waste through solid-state fermentation. The results indicate that B.

A bHLH transcription factor AaMYC2-type positively regulates glandular trichome density and artemisinin biosynthesis in Artemisia annua.

Artemisinin-based combinational therapies (ACTs) constitute the first line of malaria treatment. However, due to its trichome-specific biosynthesis, low concentration, and poor understanding of regulatory mechanisms involved in artemisinin biosynthesis and trichome development, it becomes very difficult to meet the increased demand for ACTs. Here, we have reported that a bHLH transcription factor, AaMYC2-type, plays an important role in regulating GST development and artemisinin biosynthesis in Artemisia annua.

Shaping the future: perspectives on the Integration of Artificial Intelligence in health profession education: a multi-country survey.

Background: Artificial intelligence (AI) is transforming health profession education (HPE) through personalized learning technologies. HPE students must also learn about AI to understand its impact on healthcare delivery. We examined HPE students' AI-related knowledge and attitudes, and perceived challenges in integrating AI in HPE.

Surfactant-Assisted Wet Granulation-Based Matrix Tablets without Exceptional Additives: Prolonging Systemic Exposure of Model BCS Class II Ketoprofen.

The present study was aimed to ameliorate the issue of solubility and thereby, bioavailability of ketoprofen, a BCS Class II drug. The sustained release matrix tablets (MT) were prepared using surfactant-assisted wet granulation (SAWG) with 1-5% of different surfactants. The tablet characteristics were within the compendial limits.

Is the load capacity curve a true phenomenon for OECD economies? Hidden behavior of financial institutions and markets in Environmental Sustainability.

Over the last few decades, the globe has faced severe challenges in isolating entire nations from social, economic, and environmental issues. However, rising pollution levels have become the most debatable agenda. To resolve this, the world has introduced a few green initiatives, i.

The Association of Cognitive Impairment and Depression with Malnutrition among Vulnerable, Community-Dwelling Older Adults: A Large Cross-Sectional Study.

(1) Background: Mental health issues in older adults, particularly cognitive impairment and depression, can affect nutritional status. This study investigates the prevalence of malnutrition among community-dwelling older adults at risk of social exclusion and dependency in Lebanon and its association with cognitive impairment and depression. (2) Methods: This cross-sectional study used secondary data from the TEC-MED project, involving 1410 older adults aged 60 and above in Beirut.

Unifying mortality forecasting model: an investigation of the COM-Poisson distribution in the GAS model for improved projections.

Forecasting mortality rates is crucial for evaluating life insurance company solvency, especially amid disruptions caused by phenomena like COVID-19. The Lee-Carter model is commonly employed in mortality modelling; however, extensions that can encompass count data with diverse distributions, such as the Generalized Autoregressive Score (GAS) model utilizing the COM-Poisson distribution, exhibit potential for enhancing time-to-event forecasting accuracy. Using mortality data from 29 countries, this research evaluates various distributions and determines that the COM-Poisson model surpasses the Poisson, binomial, and negative binomial distributions in forecasting mortality rates.

A conformable mathematical model of Ebola Virus Disease and its stability analysis.

Ebola Virus Disease (EVD) is a viral hemorrhagic fever that affects humans and other primates. It is characterized by rapid virus spread in a short period of time. The disease has the potential to spread to many different regions of the world.

Occurrence, antimicrobial resistance and genomic features of from broiler chicken in Faisalabad, Pakistan.

Introduction: The dissemination of antimicrobial resistance (AMR) in critical priority pathogens is a significant threat. Non-clinical reservoirs of AMR, such as agriculture and food production facilities, may contribute to the transmission of clinically relevant pathogens such as multidrug-resistant (MDR) . There is currently very limited knowledge regarding the population structure and genomic diversity of in poultry production in Pakistan.

Fabrication of Zinc Doped Titanium Dioxide Nanoparticles to Inhibit Growth and Proliferation of Liver Cancer Cells (HepG2).

The current research is related to the synthesis of different concentrations (0, 3, and 7 wt %) Zn doped TiO-NPs by using the coprecipitation method. The rutile, anatase crystal structure appeared on different diffracted peaks in TiO-NPs, and the crystallite size (12 to 24 nm) was calculated by using XRD analysis. The spherical, irregular, porous grain-like surface morphology was observed by SEM analysis, and the identification of different functional modes such as hydroxyl, -C-O, -C-O-C, and Ti-O-Ti attached on the surface of the spectrum was examined via FTIR analysis.

Uncovering the epidemiology of bladder cancer in the Arab world: A review of risk factors, molecular mechanisms, and clinical features.

Objective: Bladder cancer (BC) is a significant public health concern in the Middle East and North Africa, but the epidemiology and clinicopathology of the disease and contributors to high mortality in this region remain poorly understood. The aim of this systematic review was to investigate the epidemiological features of BC in the Arab world and compare them to those in Western countries in order to improve the management of this disease.

Methods: An extensive electronic search of the PubMed/PMC and Cochrane Library databases was conducted to identify all articles published until May 2022, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.