Publications by authors named "Abaysew Ayele"
Globally, drug-resistant tuberculosis (DR-TB) is responsible for 13% of mortality attributable to antimicrobial resistance. In Ethiopia, extrapulmonary tuberculosis (EPTB) is a significant public health challenge, and drug resistance (DR) in EPTB is often overlooked. In a cross-sectional study conducted between August 2022 and October 2023, we aimed to explore the magnitude of phenotypic drug resistance and identify genetic mutations linked to resistance using 189 Mycobacterium tuberculosis (MTB) isolates cultured from extrapulmonary clinical specimens.
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- Shigellosis is a major health issue in Ethiopia, particularly affecting young children, and is exacerbated by antimicrobial resistance due to misuse of antibiotics and poor hygiene.
- The study utilized whole genome sequencing (WGS) to examine Shigella sonnei strains in Addis Ababa, focusing on antibiotic resistance genes and plasmid types associated with these strains.
- Findings showed a variety of resistance genes and phenotypic resistance patterns, indicating significant genetic diversity in S. sonnei strains, which suggests the need for enhanced monitoring of antimicrobial resistance through WGS.