Publications by authors named "Abas Rashid Bhat"
Background And Aim: This work was conducted to compare the therapeutic potential of undifferentiated and osteogenic differentiated canine (xenogeneic) and guinea pig (allogeneic) BMSCs in fracture healing using guinea pig as a model.
Materials And Methods: A well-characterized homogenous population of third passage mesenchymal stem cells of bone marrow origin was used in all the experiments. MSCs from both the species, i.
Article Synopsis
- The study aimed to evaluate the effectiveness of canine bone marrow-derived mesenchymal stem cells (BM MSCs) in a mesh scaffold for enhancing wound healing in guinea pigs, comparing the results between fresh and cryopreserved cells.
- Both fresh and thawed BM MSCs showed similar growth rates and maintained essential cell markers, successfully differentiating into various cell types.
- Wound healing was significantly improved in groups treated with MSC-augmented meshes and fresh MSC injections, achieving over 65% contraction on day 14, outperforming the control group, and suggesting the viability of both fresh and frozen MSCs for quality wound healing.