Evaluation of Osteopontin Gene Expression in Endometrium of Diabetic Rat Models Treated with Metformin and Pioglitazone.

Background: Osteopontin () is one of the co-factors involved in cell adhesion and invasion during the implantation process. Several reports have shown expression changes in diabetic condition in several tissues. In addition, an increased incidence of spontaneous abortion is reported in diabetic women.