Publications by authors named "Abarna Thiru"
Article Synopsis
- Researchers identified and characterized two new inhibitors specifically targeting the fibroblast growth factor receptor (FGFR) family, which are important for cell signaling in various cancers.
- These inhibitors show a strong preference for FGFR over a similar receptor, VEGFR2, when tested in lab cell lines and living organisms.
- The effectiveness of these inhibitors was evaluated across different human tumor cell lines with known genetic changes that activate FGFR, suggesting their potential clinical use in treating FGFR-related diseases.
This chapter describes nuclear magnetic resonance (NMR) methods that can be used to determine the structures of protein complexes. Many of these techniques are also applicable to other systems (e.g.
View Article and Find Full Text PDFHP1 family proteins are adaptor molecules, containing two related chromo domains that are required for chromatin packaging and gene silencing. Here we present the structure of the chromo shadow domain from mouse HP1beta bound to a peptide containing a consensus PXVXL motif found in many HP1 binding partners. The shadow domain exhibits a novel mode of peptide recognition, where the peptide binds across the dimer interface, sandwiched in a beta-sheet between strands from each monomer.
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