Publications by authors named "Abarna Murugan"
Article Synopsis
- Aging significantly impacts the brain due to both external factors and changes in immune cells over time.
- Immunosenescence and Inflammaging contribute to increased inflammation and oxidative stress in the brain, elevating cytokine levels.
- This pro-inflammatory environment causes harmful alterations in brain structure and function, ultimately impairing central and neuroendocrine processes.
Glycosylation is the most common post-translational modification of proteins, and glycosylation changes at cell surfaces are frequently associated with malignant epithelia including head and neck squamous cell carcinoma (HNSCC). In HNSCC, 5-year survival remains poor, averaging around 50% globally: this is partly related to late diagnosis. Specific protein glycosylation signatures on malignant keratinocytes have promise as diagnostic and prognostic biomarkers and as therapeutic targets.
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- A live vaccine strain targeting a widespread cause of diarrheal disease in poultry was shown to significantly reduce infection levels in over 50% of vaccinated birds, creating a distinction between "responder" and "non-responder" categories.
- Further studies indicated that the immune response differed between these groups, with responder birds showing stronger antibody activity despite no major overall differences in serum glycosylation patterns.
- Interestingly, the composition of gut microbiota influenced vaccination efficacy, as transferring microbiota from responder birds to non-responders improved immune responses, highlighting the potential for these factors in developing better vaccines for poultry.
The skin barrier consists of mucus, primarily comprising highly glycosylated mucins, and the epithelium. Host mucin glycosylation governs interactions with pathogens and stress is associated with impaired epithelial barrier function. We characterized Atlantic salmon skin barrier function during chronic stress (high density) and mucin -glycosylation changes in response to acute and chronic stress.
View Article and Find Full Text PDFDisease outbreaks are limiting factors for an ethical and economically sustainable aquaculture industry. The first point of contact between a pathogen and a host occurs in the mucus, which covers the epithelial surfaces of the skin, gills and gastrointestinal tract. Increased knowledge on host-pathogen interactions at these primary barriers may contribute to development of disease prevention strategies.
View Article and Find Full Text PDFDiseases cause ethical concerns and economic losses in the Salmonid industry. The mucus layer comprised of highly -glycosylated mucins is the first contact between pathogens and fish. Mucin glycans govern pathogen adhesion, growth and virulence.
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