Role of Altmetric Attention Scores in Evaluating the Influence of Spine Surgery Research.

Study Design: Retrospective cohort.

Objective: To analyze the annual trends in the most prevalent topics, journals, and geographic regions of the top 100 spine surgery articles, as determined by altmetric attention scores (AASs). We also describe the relationship between AAS and traditional article metrics.

Repurposing fluvoxamine as an inhibitor for NUDT5 in breast cancer cell: an in silico and in vitro study.

Unlabelled: Drug repurposing is necessary to accelerate drug discovery and meet the drug needs. This study investigated the possibility of using fluvoxamine to inhibit the cellular metabolizing enzyme NUDT5 in breast cancer. Computational and experimental techniques were used to evaluate the structural flexibility, binding stability, and chemical reactivity of the drugs.

Understanding the Formation Dynamics and Physical Properties of Nanocapsules Using Charge Detection Mass Spectrometry.

Characterizing the size, structure, and composition of nanoparticles is vital in predicting and understanding their macroscopic properties. In this work, charge detection mass spectrometry (CDMS) was used to analyze nanocapsules (∼10-200 MDa) consisting of a liquid oleic acid core surrounded by a dense silica outer shell. CDMS is an emerging method for nanoparticle analysis that can rapidly measure the mass and charge of thousands of individual nanoparticles.

Surgeon's perceptions and preferences in the management of idiopathic macular hole.

Purpose: The management of idiopathic macular holes (iMH) has evolved over time with various modifications in surgical approach. The study aimed to survey the surgeons' preferences in the management of iMH in current times.

Design: Cross-sectional descriptive survey.

Profile and outcomes of retinal artery occlusion: The underrealized need to expedite presentation.

Purpose: To evaluate the clinical profile of retinal artery occlusion (RAO) and impact of presentation on visual outcomes.

Design: A retrospective analysis of case files of 3070 patients with RAO was performed using electronic medical records.

Methods: Demographic data were analyzed using descriptive statistics.

Neurohistopathological findings of the brain parenchyma after long-term deep brain stimulation: Case series and systematic literature review.

Introduction: Efficacy of deep brain stimulation (DBS) is established for several movement and psychiatric disorders. However, the mechanism of action and local tissue changes are incompletely described. We describe neurohistopathological findings of 9 patients who underwent DBS for parkinsonism and performed a systematic literature review on postmortem pathologic reports post-DBS.

A novel placement method of a calibration-free pH capsule for continuous wireless measurement of intragastric pH in horses.

Background: Current methods to measure intragastric pH in horses have limitations. A wireless capsule has been designed for continuous esophageal pH monitoring in humans.

Objectives: To (1) determine the feasibility and describe the methodology of measuring intragastric pH wirelessly in horses; and (2) determine attachment duration of the capsules.

Multifunctional luminogens with synergy of aggregation-induced delayed fluorescence, two-photon absorption and photocurrent generation.

In this study, we investigated the aggregation-induced delayed fluorescence (AIDF) properties of three luminogens - TN, TA, and TP. Our comprehensive theoretical analysis reveals a significant reduction in the Δ in their aggregated or solid-state, activating TADF, on a ∼μs time-scale. Additionally, these luminogens demonstrate two-photon excited anti-Stokes photoluminescence emission and improved photocurrent generation, attributed to their strong charge transfer characteristics and longer singlet exciton lifetimes.

Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung.

Airway multiciliated cells (MCs) maintain respiratory health by clearing mucus and trapped particles through the beating of motile cilia. While it is known that ciliary lengths decrease along the proximal-distal (P-D) axis of the tracheobronchial tree, how this is regulated is unclear. Here, we demonstrate that canonical Notch signaling in MCs plays a critical role in stabilizing ciliary length.

Hydroxyl chalcone derivative DK02 as a multi-target-directed ligand for Alzheimer's disease: A preclinical study in zebrafish.

Background And Purpose: Alzheimer's disease (AD) is a widespread neurodegenerative condition characterized by amyloid-beta (Aβ) plaques and tau protein aggregates, leading to significant cognitive decline. Existing treatments primarily offer symptomatic relief, underscoring the urgent need for novel therapies that address multiple AD pathways. This study evaluates the efficacy of DK02, a hydroxyl chalcone derivative, in a scopolamine-induced dementia model in zebrafish, hypothesizing that it targets several neurodegenerative mechanisms simultaneously.

Genetic and allelic heterogeneity in 248 Indians with skeletal dysplasia.

Skeletal dysplasias are a clinically and genetically heterogeneous group of rare disorders. Studies from large cohorts are essential to provide insights into the disease epidemiology, phenotypic spectrum, and mutational profiles. Here we enumerate additional 248 Indians from 197 families with a skeletal dysplasia, following a similar study earlier.

Generation and validation of a D1 dopamine receptor Flpo knock-in mouse.

Background: Dopamine is a powerful neuromodulator of diverse brain functions, including movement, motivation, reward, and cognition. D1-type dopamine receptors (D1DRs) are the most prevalently expressed dopamine receptors in the brain. Neurons expressing D1DRs are heterogeneous and involve several subpopulations.

Caregiver Distress: An Interdisciplinary Approach to Patient Care.

Background: Advanced cancer severely impacts the lives of patients as well as their caregivers and loved ones. The burden of the caregiver role often results in significant distress, especially near the end of life. Identifying ways to support patients and caregivers is an important focus of palliative care.

Comparative evaluation of the influence of the palatal root length on the efficacy of maxillary buccal infiltration by open and closed mouth technique: a randomized control trial.

Background: Maxillary molars are commonly anesthetized via buccal infiltration. A patient's mouth opening during maxillary buccal infiltration can influence dental treatment. Hence, this study aimed to evaluate and compare the influence of palatal root length on the efficacy of 2% lidocaine in 1:80000 adrenaline for maxillary buccal infiltration (MBI) between the open- and closed-mouth techniques.

STABLE trial of spectacle provision and driving safety among myopic motorcycle users in Vietnam: study protocol for a stepped-wedge, cluster randomised trial.

Background: Traffic crashes are the leading cause of death globally for people aged 5-29 years, with 90% of mortality occurring in low- and middle-income countries (LMICs). The STABLE (Slashing Two-wheeled Accidents by Leveraging Eyecare) trial was designed to determine whether providing spectacles could reduce risk among young myopic motorcycle users in Vietnam.

Methods: This investigator-masked, stepped-wedge, cluster randomised naturalistic driving trial will recruit 625 students aged 18-23 years, driving ≥ 50 km/week, with ≥ 1-year driving experience and using motorcycles as their primary means of transport, in 25 clusters of 25 students in Ho Chi Minh City, Vietnam.

Investigations on the saline groundwater pumping method and its impact on active saltwater intrusion on a layered aquifer system.

Active saltwater intrusion (ASWI) accelerates and intensifies salinization due to buoyancy force-induced density differences and concurrent inland fresh groundwater flow. This study investigates saline groundwater (SGW) pumping as a remediation technique for ASWI through experimental and field-scale analyses in a layered aquifer system characterised by diminishing permeability with depth. Experiments demonstrated that higher permeability layers reduced length of intrusion (Ltoe) whereas lower permeability layers restricted vertical displacement.

Speech Perception and Language Abilities Among Children Using Cochlear Implants: Findings From a Primary School Age Cohort in South India.

Objectives: This study aimed to profile the speech perception and language abilities of a cohort of pediatric cochlear implant (CI) users in primary school years. It also aimed to understand the intercorrelations among audiological, child, and environmental characteristics, speech perception, and language skills and to explore the predictors of speech perception and language skills.

Design: A cross-sectional design was used for the study.

Systems biology-enabled targeting of NF-κB and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL.

Unlabelled: In Diffuse Large B-cell Lymphoma (DLBCL), elevated anti-apoptotic BCL2-family proteins (e.g., MCL1, BCL2, BCLXL) and NF-κB subunits (RelA, RelB, cRel) confer poor prognosis.

Colours of India: Uniting Endocrinologists in Fitness and Friendship.

Colours of India is an annual cultural phenomenon that transcends the boundaries of professional conferences, uniting endocrinologists through the universal language of music and dance. Since its inception in 2016, this vibrant event has brought together teams from across India and other participating countries, showcasing diverse dance forms while fostering friendships, promoting wellness, and celebrating cultural diversity within the medical community.

Profile of Falls and Its Associated Factors among Adults with Visual Impairment: A Cross-sectional Study from a Tertiary Eye Hospital.

Background: Falls among adults with visual impairment (VI) are underreported or underrepresented compared to elderly falls.

Objectives: To report falls among the young, middle-aged, and elderly adults with VI.

Materials And Methods: This cross-sectional study recruited subjects from a tertiary eye care center with VI aged ≥18 years based on clinical records.

High sensitivity direct magnetic field detection based metrology for ultra-thin magnetic films and Li-ion cells.

Ultra-low magnetic field sensing is emerging as a tool for materials' diagnostics, particularly for the operando studies of electrochemical systems. A magnetic metrology system having the capability of sensing fields as low as ∼1.88 pT has been setup for such studies using a commercial atomic magnetometer.

Comparison of Microleakage and Bond Strength in Metal and Ceramic Brackets Cured by Conventional and Transillumination Methods: An Evaluation.

Background: The study explores the impact of microleakage on bracket (metal/ceramic) debonding and the occurrence of white spot lesions during orthodontic treatment. Various curing techniques are employed to assess shear bond strength (SBS) and microleakage in both metal and ceramic brackets.

Materials And Methods: A total of 120 samples were divided into six groups, each consisting of 20 samples.

SpecGMM: Integrating Spectral analysis and Gaussian Mixture Models for taxonomic classification and identification of discriminative DNA regions.

Motivation: Genomic signal processing (GSP), which transforms biomolecular sequences into discrete signals for spectral analysis, has provided valuable insights into DNA sequence, structure, and evolution. However, challenges persist with spectral representations of variable-length sequences for tasks like species classification and in interpreting these spectra to identify discriminative DNA regions.

Results: We introduce SpecGMM, a novel framework that integrates sliding window-based Spectral analysis with a Gaussian Mixture Model to transform variable-length DNA sequences into fixed-dimensional spectral representations for taxonomic classification.