Bioethics: cancelling patient operations.

Purpose Of Review: This review aims to surmise a bioethical approach to the phenomenon of cancelling patient operations. There is increasing public and political interest in the matter with a rise in the frequency of cancellations. Cancellations are emotional for patients and are difficult clinical decisions.

Insulin down-regulates cardioprotective SUR2A in the heart-derived H9c2 cells: A possible explanation for some adverse effects of insulin therapy.

Some recent studies associated insulin therapy with negative cardiovascular events and shorter lifespan. SUR2A, a K channel subunit, regulate cardioprotection and cardiac ageing. Here, we have tested whether glucose and insulin regulate expression of SUR2A/K channel subunits and resistance to metabolic stress in heart H9c2 cells.