Publications by authors named "Aashna Calidas"
53BP1 plays a crucial role in regulating DNA damage repair pathway choice and checkpoint signaling in somatic cells; however, its role in meiosis has remained enigmatic. In this study, we demonstrate that the Caenorhabditis elegans ortholog of 53BP1, HSR-9, associates with chromatin in both proliferating and meiotic germ cells. Notably, HSR-9 is enriched on the X chromosome pair in pachytene oogenic germ cells.
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- The protein 53BP1 is important for DNA damage repair and checkpoint signaling in somatic cells, while its function in meiosis is less understood.
- The study reveals that HSR-9, the counterpart of 53BP1, binds to chromatin in both growing and meiotic germ cells, showing higher levels on chromosome pairs in specific stages of oogenesis.
- HSR-9 influences the processing of amino acid sequences in meiotic double strand breaks and contributes to chromosome segregation, indicating it has both shared and distinct roles compared to its ortholog in somatic cells.
Introduction: Incidence of peritoneal carcinomatosis (PC) after curative resection of stage II and III colon cancer varies widely. Although certain features are considered high risk for PC, the impact of these features on PC incidence is unclear.
Methods: A retrospective analysis was performed on patients ≥ 18 years old with resected stage II and III colonic adenocarcinoma treated at two academic institutions from 2007 to 2018.