Publications by authors named "Aasha Gupta"

Although immune checkpoint blockade (ICB) is currently approved for the treatment of extensive-stage small-cell lung cancer (SCLC) in combination with chemotherapy, relatively few patients have demonstrated durable clinical benefit (DCB) to these therapies. Biomarkers predicting responses are needed. Biopsies from 35 SCLC patients treated with ICB were subjected to transcriptomic analysis; gene signatures were assessed for associations with responses.

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Article Synopsis
  • Many patients treated with FDA-approved CAR T cells see their disease progress, especially with solid cancers and certain types of blood cancers like T cell lymphomas.
  • A major challenge in adoptive T cell therapies is the dysfunction of CAR T cells, which struggle to expand and last after being infused.
  • The study reveals that knocking out the CD5 gene using CRISPR-Cas9 can improve the antitumor abilities of CAR T cells by enhancing their function and persistence, suggesting CD5 as a key target for improving T cell therapies.
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Article Synopsis
  • - The study identifies the interaction between BTLA on T cells and HVEM on regulatory T cells as a major factor limiting the effectiveness of T cell-based immunotherapies in tumors.
  • - High levels of BTLA in CAR T cells are linked to poorer treatment outcomes, prompting researchers to delete BTLA to improve the T cells' tumor-fighting abilities.
  • - By removing BTLA, T cells show enhanced signaling and function, suggesting that targeting the BTLA-HVEM interaction could boost the success of CAR T cell therapies.
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Novel screening techniques for early detection of lung cancer are urgently needed. Profiling circulating tumor cell-free DNA (ctDNA) has emerged as a promising tool for biopsy-free tumor genotyping. However, both the scarcity and short half-life of ctDNA substantially limit the sensitivity and clinical utility of ctDNA detection methodologies.

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