Publications by authors named "Aaryan Chhabra"
A Mathematical Model-Derived Disposition Index Without Insulin Validated in Youth with Obesity.
J Clin Endocrinol Metab
August 2024
Article Synopsis
- The study aimed to validate a new mathematical model for measuring insulin sensitivity and β-cell function, as traditional methods are impractical for large-scale research.
- The researchers used data from previous studies involving 130 obese youths to compare their model-derived indices against standard clamp measurements and other indices.
- The findings indicated that the new model (mDI-woI) was more effective at detecting insulin resistance and prediabetes than traditional methods, suggesting it could serve as a cost-effective tool for large epidemiological studies.
Efficient and accurate methods to estimate insulin sensitivity () and β-cell function (BCF) are of great importance for studying the pathogenesis and treatment effectiveness of type 2 diabetes (T2D). Existing methods range in sensitivity, input data, and technical requirements. Oral glucose tolerance tests (OGTTs) are preferred because they are simpler and more physiological than intravenous methods.
View Article and Find Full Text PDF