Publications by authors named "Aarti Balasubramani"
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Synopsis of recent research by authors named "Aarti Balasubramani"
- Aarti Balasubramani's research focuses on developing innovative T-cell engagers (TCEs) and bispecific antibodies that selectively target tumor cells while minimizing off-target toxicities, particularly for cancers such as ovarian cancer and metastatic castration-resistant prostate cancer (mCRPC).
- Her studies include the design of a bivalent bispecific antibody targeting folate receptor alpha (FRα) to enhance tumor selectivity in ovarian cancer and a PSMAxCD3 bispecific antibody that reduces pro-inflammatory cytokine release while remaining effective against prostate tumors.
- Additionally, she explores the potential of heavy chain-only antibodies for creating multispecific antibody platforms, which offer a novel approach to building diverse therapeutic biologics without the constraints of traditional light chain-dependent structures.
