Publications by authors named "Aart H G van Assen"
Bone is a dynamic tissue that is maintained by continuous renewal. An imbalance in bone resorption and bone formation can lead to a range of disorders, such as osteoporosis. The receptor activator of NF-κB (RANK)-RANK-ligand (RANKL) pathway plays a major role in bone remodeling.
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- The Pseudomonas aeruginosa PAO1 bacteria has genes that can break down special molecules called acylhomoserine lactones (AHLs), which help them communicate and cause illness.
- Scientists looked closer at one of these genes called pa0305 to see if it could also break down AHLs and found it could do so effectively.
- When they increased the activity of the pa0305 gene, the bacteria made less of the harmful AHL molecules and became less harmful to tiny worms used in their experiments.
Characterization of the binding of a tumor necrosis factor (TNF) ligand to its receptor(s) is pivotal to understand how these proteins initiate signal transduction pathways. Unfortunately, kinetic elucidation of these interactions is strongly hampered by the multivalent nature of the binding partners. The interaction between TNF-related apoptosis-inducing ligand and its death receptors was analyzed using in-depth applications of surface plasmon resonance technology.
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