Publications by authors named "Aaron Zou"
Article Synopsis
- Heart failure (HF) is a common heart problem, but scientists don't completely understand why it happens.
- A specific splicing factor called hnRNPL gets more active in the hearts of mice and people with heart failure.
- Researchers found that hnRNPL helps control how certain proteins are made in heart cells, and problems with it could contribute to heart failure.
Heterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5.
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