Publications by authors named "Aaron Ye"
Introduction: In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods: A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Article Synopsis
- Ovarian cancer is a significant health issue, being the fifth leading cause of cancer deaths in women, with late-stage disease characterized by tumor spheroids that resist environmental stress.
- Rgnef, a guanine nucleotide exchange factor, is found to be elevated in late-stage ovarian cancer and is linked to poorer patient prognosis, as its increased levels correlate with decreased survival rates, while its loss is associated with better outcomes.
- Research indicates that Rgnef is crucial for the formation of ovarian spheroids and tumor growth, and it supports an antioxidant gene signature that protects cancer cells from oxidative stress, highlighting its potential role in cancer progression and therapy.