Publications by authors named "Aaron Wei Liang Li"
Article Synopsis
- Variegin and its variant, ultravariegin (UV), have shown potential in early studies for improving blood clot inhibition without the bleeding risks associated with traditional drugs like heparin.
- PEGylation, a technique that attaches PEG chains to the UV peptide, significantly enhances its circulation time and effectiveness, allowing for prolonged anticoagulant effects in animal models while maintaining its efficacy.
Activated factor XI (FXIa) is an important antithrombotic drug target. Clinical and pre-clinical data have demonstrated that its inhibition attenuates thrombosis with minimal risk of excessive bleeding. We isolated Fasxiator from the venom of banded krait Bungarus fasciatus and subsequently engineered FasxiatorN17R,L19E, with improved affinity (Ki = 0.
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- Unfractionated heparin (UFH) and bivalirudin are commonly used anticoagulants during percutaneous coronary intervention (PCI), but researchers have identified new direct thrombin inhibitors (DTIs) from tick saliva that may perform better.
- The most effective DTI, ultravariegin, inhibits thrombin significantly more effectively than bivalirudin and shows a significantly reduced risk of bleeding in animal models.
- When tested with common antiplatelet medications, ultravariegin not only lowered stent thrombosis but also exhibited a remarkable safety profile, indicating its potential as a safer alternative for PCI procedures.
We recently discovered that Mfsd2b, which is the S1P exporter found in blood cells. Here, we report that Mfsd2b is critical for the release of all S1P species in both resting and activated platelets. We show that resting platelets store S1P in the cytoplasm.
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