CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues.

Background: Cis-regulatory elements (CREs) play a pivotal role in gene expression regulation, allowing cells to serve diverse functions and respond to external stimuli. Understanding CREs is essential for personalized medicine and disease research, as an increasing number of genetic variants associated with phenotypes and diseases overlap with CREs. However, existing databases often focus on subsets of regulatory elements and present each identified instance of element individually, confounding the effort to obtain a comprehensive view.

SARS-CoV-2 viral load assessment in respiratory samples.

Real-time reverse transcriptase polymerase chain reaction (rRTPCR) has been the main method for diagnosis of SARS-CoV-2 infection in the early stages of the COVID-19 pandemic. De-identified results from upper and lower respiratory samples submitted to a reference laboratory demonstrated a positivity rate of 14.9 % (4428 of 29,713 samples tested).

Management of severe traumatic flexion-distraction injuries in a multisystem trauma patient: A case report.

Study Design: Case report and relevant literature review.

Objective: To discuss the management of severe flexion-distraction injury of the subaxial cervical spine in a multisystem trauma patient.

Summary Of Background Data: Traumatic cervical spine injury from flexion-distraction injury can cause significant instability requiring extensive instrumentation complicated by vascular and soft tissue injuries.