Publications by authors named "Aaron S Mohammed"
Article Synopsis
- Organismal aging leads to declines in both bodily and reproductive functions, with various strategies identified to extend lifespan across different species.
- The study created the Cell Atlas of Worm Aging (CAWA) to analyze age-related molecular changes in different cell types, revealing unique aging signatures and developing aging clocks for various tissues.
- It also uncovered cell-specific changes in alternative polyadenylation (APA) during aging and how different lifespan-extending strategies uniquely impact these changes, enhancing understanding of aging mechanisms.
Article Synopsis
- The research investigates how aging occurs at the multicellular level, focusing on the effects of pro-longevity mechanisms on various cell types in Caenorhabditis elegans.
- By creating single-cell transcriptomic atlases, the study identifies age-related changes in somatic and germ cell types and develops aging clocks for different tissues.
- The findings reveal tissue-specific aging responses to pro-longevity mechanisms and provide insights into molecular changes linked to aging and alternative polyadenylation events across different cell types.
Proteomic analysis revealed the preservation of many proteins in the Heslington brain (which is at least 2600-year-old brain tissue uncovered within the skull excavated in 2008 from a pit in Heslington, Yorkshire, England). Five of these proteins-"main proteins": heavy, medium, and light neurofilament proteins (NFH, NFM, and NFL), glial fibrillary acidic protein (GFAP), and myelin basic (MBP) protein-are engaged in the formation of non-amyloid protein aggregates, such as intermediate filaments and myelin sheath. We used a wide spectrum of bioinformatics tools to evaluate the prevalence of functional disorder in several related sets of proteins, such as the main proteins and their 44 interactors, all other proteins identified in the Heslington brain, as well as the entire human proteome (20,317 manually curated proteins), and 10,611 brain proteins.
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