Publications by authors named "Aaron Refisch"
Article Synopsis
- T regulatory (Treg) cells play a key role in maintaining immune tolerance by preventing harmful inflammation through various immunosuppressive mechanisms, both contact-dependent and independent.
- Recent studies highlight that Treg cells secrete extracellular vesicles (EVs) as a novel way to modulate immune responses without direct cell contact, which may be influential in various diseases.
- The EVs facilitate intercellular communication by transmitting proteins, lipids, and genetic material, and they can create a tolerogenic environment, suggesting Treg cells have a potential role in managing immune responses during inflammation and possibly in regulating CD4 T cell differentiation.
Several mechanisms of immune suppression have been attributed to Foxp3+ T regulatory cells (Treg) including modulation of target cells via inhibition of cell proliferation, alteration of cytokine secretion, and modification of cell phenotype, among others. Neuropilin-1 (Nrp1), a co-receptor protein highly expressed on Treg cells has been involved in tolerance-mediated responses, driving tumor growth and transplant acceptance. Here, we extend our previous findings showing that, despite expressing Foxp3, Treg cells have deficient suppressive function in a contact-independent manner.
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