Publications by authors named "Aaron R Froese"
Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis.
Am J Respir Crit Care Med
July 2016
Rationale: Recent findings suggesting transforming growth factor (TGF)-β1 activation by mechanical stimuli in vitro raised the question of whether this phenomenon was relevant in vivo in the context of pulmonary fibrosis.
Objectives: To explore the effect of mechanical stress on TGF-β1 activation and its signaling pathway in rat and human fibrotic lung tissue using a novel ex vivo model.
Methods: Rat lung fibrosis was induced using transient gene expression of active TGF-β1.