TsrA Regulates Virulence and Intestinal Colonization in .

Pathogenic strains of require careful regulation of horizontally acquired virulence factors that are largely located on horizontally acquired genomic islands (HAIs). While TsrA, a -specific protein, is known to regulate the critical HAI virulence genes and , its broader function throughout the genome is unknown. Here, we find that deletion of results in genomewide expression patterns that heavily correlate with those seen upon deletion of , a widely conserved bacterial protein that regulates virulence.

ToxR Antagonizes H-NS Regulation of Horizontally Acquired Genes to Drive Host Colonization.

The virulence regulator ToxR initiates and coordinates gene expression needed by Vibrio cholerae to colonize the small intestine and cause disease. Despite its prominence in V. cholerae virulence, our understanding of the direct ToxR regulon is limited to four genes: toxT, ompT, ompU and ctxA.