Effect of Training on Visual Identification of High Frequency Oscillations-A Delphi-Style Intervention.

Objective: We examined the effect of a simple Delphi-method feedback on visual identification of high frequency oscillations (HFOs) in the ripple (80-250 Hz) band, and assessed the impact of this training intervention on the interrater reliability and generalizability of HFO evaluations.

Methods: We employed a morphology detector to identify potential HFOs at two thresholds and presented them to visual reviewers to assess the probability of each epoch containing an HFO. We recruited 19 board-certified epileptologists with various levels of experience to complete a series of HFO evaluations during three sessions.

Disseminated intravascular coagulation from disseminated histoplasmosis in uncontrolled HIV - Case report.

This case report describes an atypical presentation of a relatively common opportunistic infection, without documented exposure to areas known at the time to be endemic, resulting in catastrophic complications. The patient presented with a two month progressive history of vomiting, diarrhea, productive cough, and shortness of breath, on the background of poorly-controlled HIV. There was a low index of suspicion for infection with histoplasmosis, particularly given the large differential diagnosis and the lack of travel or endemic precedence.

Graph index complexity as a novel surrogate marker of high frequency oscillations in delineating the seizure onset zone.

Objective: To investigate the Graph Index Complexity (uGIC) as a marker of high frequency oscillatory (HFO) activity, the seizure onset zone (SOZ), and surgical outcome.

Methods: The SOZ, rates of HFOs at two thresholds (broad, strict), and uGIC were determined using EEG data from 41 patients. The correlation between HFOs and uGIC were calculated.

Generalizability of High Frequency Oscillation Evaluations in the Ripple Band.

We examined the interrater reliability and generalizability of high-frequency oscillation (HFO) visual evaluations in the ripple (80-250 Hz) band, and established a framework for the transition of HFO analysis to routine clinical care. We were interested in the interrater reliability or epoch generalizability to describe how similar the evaluations were between reviewers, and in the reviewer generalizability to represent the consistency of the internal threshold each individual reviewer. We studied 41 adult epilepsy patients (mean age: 35.

Interrater reliability of visually evaluated high frequency oscillations.

Objective: High frequency oscillations (HFOs) and interictal epileptiform discharges (IEDs) have been shown to be markers of epileptogenic regions. However, there is currently no 'gold standard' for identifying HFOs. Accordingly, we aimed to formally characterize the interrater reliability of HFO markings to validate the current practices.