Publications by authors named "Aaron Lisman"
The Data Coordinating Center (DCC) of the Human Tumor Atlas Network (HTAN) has played a crucial role in enabling the broad sharing and effective utilization of HTAN data within the scientific community. Data from the first phase of HTAN are now available publicly. We describe the diverse datasets and modalities shared, multiple access routes to HTAN assay data and metadata, data standards, technical infrastructure and governance approaches, as well as our approach to sustained community engagement.
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- International cancer registries, like AACR Project GENIE, provide access to genomic and clinical data from over 130,000 cancer patients, but analyzing this combined data can be tricky.
- The cBioPortal for Cancer Genomics has improved its features to help visualize and analyze longitudinal clinical and genomic data, allowing users to see how treatment impacts patient outcomes over time.
- These enhancements enable researchers and clinicians to explore complex datasets, fostering discoveries on how specific genomic changes affect cancer prognosis and treatment effectiveness.
Purpose: Interpretation of genomic variants in tumor samples still presents a challenge in research and the clinical setting. A major issue is that information for variant interpretation is fragmented across disparate databases, and aggregation of information from these requires building extensive infrastructure. To this end, we have developed Genome Nexus, a one-stop shop for variant annotation with a user-friendly interface for cancer researchers and clinicians.
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