Publications by authors named "Aaron H Y Chan"

Background: This study aims to investigate the association of pre-conception vitamin D levels on adverse pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer.

Methods: This was a retrospective cohort study using archived serum 25-hydroxyvitamin D measured in the pre-conception period before ovarian stimulation in patients undergoing in vitro fertilization with fresh autologous embryo transfer. A total of 306 women were included and adverse pregnancy outcomes in their resulting pregnancy were recorded.

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Introduction: Patients with advanced ovarian cancer often require radical cytoreductive surgery and chemotherapy, with or without targeted therapy. Return to intended oncological therapy after surgery is a crucial metric, as delay can worsen survival. The concept of return to intended oncological therapy is important because it highlights the need for not just successful surgical outcomes, but also the ability to continue with the comprehensive cancer treatment plan.

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Article Synopsis
  • The study assessed the agreement of HPV test results between self-collected samples and clinician-collected samples using two different HPV assays: Sentis (isothermal amplification) and Onclarity (PCR-based).
  • Among 104 women, the concordance rates were high, with 89.8% between Self-Sentis and Clinician-Sentis, and 84.4% between Self-Sentis and Clinician-Onclarity.
  • The findings showed that a significant number (65%) of participants found self-sampling to be acceptable, mainly due to reduced embarrassment and convenience.
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Lymph node status is important in predicting the prognosis and guiding adjuvant treatment in endometrial cancer. However, previous studies showed that systematic lymphadenectomy conferred no therapeutic values in clinically early-stage endometrial cancer but might lead to substantial morbidity and impact on the quality of life of the patients. The sentinel lymph node is the first lymph node that tumor cells drain to, and sentinel lymph node biopsy has emerged as an acceptable alternative to full lymphadenectomy in both low-risk and high-risk endometrial cancer.

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