Sjögren's Syndrome Caused by PD-1 Inhibition in a Lung Cancer Patient.

In this report, we present a patient with metastatic non-small cell lung cancer who developed Sjögren's syndrome secondary to immune checkpoint inhibition. This patient had a typical clinical presentation as well as biochemical signature, developing only 18 months after the start of treatment with PD-1 inhibition (pembrolizumab).

Intra- and inter-observer reliability of measurements on 3D images of the calcaneus bone.

The use of the 3D orientation angle of the calcaneal posterior subtalar (PTC) joint facet might be superior to the Böhler's angle to evaluate the quality of reduction after performing an open reduction and internal fixation (ORIF) of displaced intra-articular calcaneal fractures (DIACFs). : Three-Dimensional segmentations of the preoperative, postoperative and uninjured calcaneus of 54 patients with a DIACF were assessed by 4 observers with different medical backgrounds. After the delineating of the PTC on the 3D images, a MeVisLab™ software calculated the 3D orientation angle of the PTC, which was determined as the average of the angles between the normal vectors of the PTC and the main axis of the calcaneus, calculated by principal component analysis.