Exercise-specific adaptations in human skeletal muscle: Molecular mechanisms of making muscles fit and mighty.

The mechanisms leading to a predominantly hypertrophied phenotype versus a predominantly oxidative phenotype, the hallmarks of resistance training (RT) or aerobic training (AT), respectively, are being unraveled. In humans, exposure of naïve persons to either AT or RT results in their skeletal muscle exhibiting generic 'exercise stress-related' signaling, transcription, and translation responses. However, with increasing engagement in AT or RT, the responses become refined, and the phenotype typically associated with each form of exercise emerges.

Low baseline ribosome-related gene expression and resistance training-induced declines in ribosome-related gene expression are associated with skeletal muscle hypertrophy in young men and women.

Ribosomes are essential cellular machinery for protein synthesis. It is hypothesised that ribosome content supports muscle growth and that individuals with more ribosomes have greater increases in muscle size following resistance training (RT). Aerobic conditioning (AC) also elicits distinct physiological adaptations; however, no measures of ribosome content following AC have been conducted.

Aerobic conditioning alters the satellite cell and ribosome response to acute eccentric contractions in young men and women.

Satellite cells (SCs) and ribosomes are key determinants of the skeletal muscle adaptive response. Both are thought to increase acutely after resistance exercise and chronically with resistance training. However, the acute SC and ribosome exercise response with prior aerobic conditioning is unknown.

Short-term aerobic conditioning prior to resistance training augments muscle hypertrophy and satellite cell content in healthy young men and women.

Factors influencing inter-individual variability of responses to resistance training (RT) remain to be fully elucidated. We have proposed the importance of capillarization in skeletal muscle for the satellite cell (SC) response to RT-induced muscle hypertrophy, and hypothesized that aerobic conditioning (AC) would augment RT-induced adaptations. Fourteen healthy young (22 ± 2 years) men and women underwent AC via 6 weeks of unilateral cycling followed by 10 weeks of bilateral RT to investigate how AC alters SC content, activity, and muscle hypertrophy following RT.

An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise-Induced Human Skeletal Muscle Hypertrophy.

Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a highly adaptable tissue that responds to resistance exercise (RE; loading) by hypertrophying, or during muscle disuse, RE mitigates muscle loss. Resistance exercise training (RET)-induced skeletal muscle hypertrophy is a product of external (e.

Erratum: McKendry, J., et al. Nutritional Supplements to Support Resistance Exercise in Countering the Sarcopenia of Aging. 2020, , 2057.

The authors would like to correct an omission in a published paper [...

Nutritional Supplements to Support Resistance Exercise in Countering the Sarcopenia of Aging.

Skeletal muscle plays an indispensable role in metabolic health and physical function. A decrease in muscle mass and function with advancing age exacerbates the likelihood of mobility impairments, disease development, and early mortality. Therefore, the development of non-pharmacological interventions to counteract sarcopenia warrant significant attention.

Muscle Mass Loss in the Older Critically Ill Population: Potential Therapeutic Strategies.

Skeletal muscle plays a critical role in everyday life, and its age-associated reduction has severe health consequences. The pre-existing presence of sarcopenia, combined with anabolic resistance, protein undernutrition, and the pro-catabolic/anti-anabolic milieu induced by aging and exacerbated in critical care, may accelerate the rate at which skeletal muscle is lost in patients with critical illness. Advancements in intensive care unit (ICU)-care provision have drastically improved survival rates; therefore, attention can be redirected toward other significant issues affecting ICU patients (e.

Age-related changes to the satellite cell niche are associated with reduced activation following exercise.

Skeletal muscle satellite cell (SC) function and responsiveness is regulated, in part, through interactions within the niche, in which they reside. Evidence suggests that structural changes occur in the SC niche as a function of aging. In the present study, we investigated the impact of aging on SC niche properties.

Examining the first-person perspective as appropriate prelaboratory preparation.

Prelaboratory tasks are used to facilitate learning and introduce and provide context for laboratory work. The application of first-person perspective (FPP) technology may provide interesting new approaches to providing prelaboratory preparation. However, there is limited knowledge as to whether this perspective is useful or enjoyable for students preparing for laboratory tasks.

The Reliability of 4-Minute and 20-Minute Time Trials and Their Relationships to Functional Threshold Power in Trained Cyclists.

Purpose: The mean power output (MPO) from a 60-min time trial (TT)-also known as functional threshold power, or FTP-is a standard measure of cycling performance; however, shorter performance tests are desirable to reduce the burden of performance testing. The authors sought to determine the reliability of 4- and 20-min TTs and the extent to which these short TTs were associated with 60-min MPO.

Methods: Trained male cyclists (n = 8; age = 25 [5] y; VO2max = 71 [5] mL/kg/min) performed two 4-min TTs, two 20-min TTs, and one 60-min TT.

The influence of capillarization on satellite cell pool expansion and activation following exercise-induced muscle damage in healthy young men.

Key Points: Skeletal muscle stem cells (satellite cells) play a crucial role in repair and remodelling of muscle in response to exercise. Satellite cells are in close spatial proximity to muscle capillaries and therefore may be influenced by them. In this study, we describe the activation and expansion of the satellite cell pool in response to eccentric contraction-induced muscle damage in individuals with significantly different levels of muscle capillarization.