Publications by authors named "Aaron Buckley"
Motor execution, observation, and imagery are important skills used in motor learning and rehabilitation. The neural mechanisms underlying these cognitive-motor processes are still poorly understood. We used a simultaneous recording of functional near-infrared spectroscopy (fNIRS) and electroencephalogram (EEG) to elucidate the differences in neural activity across three conditions requiring these processes.
View Article and Find Full Text PDFCell Biology of Tight Junction Barrier Regulation and Mucosal Disease.
Cold Spring Harb Perspect Biol
January 2018
Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a selectively permeable barrier that supports nutrient absorption and waste secretion while preventing intrusion by luminal materials. Intestinal epithelia therefore play a central role in regulating interactions between the mucosal immune system and luminal contents, which include dietary antigens, a diverse intestinal microbiome, and pathogens.
View Article and Find Full Text PDFArticle Synopsis
- Epithelial cells that line tubular organs are essential for creating and expanding lumens, and issues in this process can lead to serious developmental problems.
- The study identifies ZO-1, a key tight junction protein, as necessary for proper single lumen formation; without it, epithelial cells form cysts with multiple lumens and show polarization defects.
- Specific regions of ZO-1, particularly the actin-binding region and U5-GuK domain, play critical roles in this process, and interactions with the protein occludin are crucial for regulating epithelial polarization and ensuring correct lumen formation.