Marine-Derived Furanones Targeting Quorum-Sensing Receptors in : Molecular Insights and Potential Mechanisms of Inhibition.

The quorum-sensing (QS) machinery in disease-causing microorganisms is critical in developing antibiotic resistance. In , QS is involved in biofilm formation, virulence factors production, and general tolerance to antimicrobials. Owing to the major role QS plays, interference in the process is probably a facile route to overcome antimicrobial resistance.

Molecular insights into the differential membrane targeting of maximin 1 in prokaryotic and eukaryotic cells.

Antimicrobial resistance is a pressing global health concern, underscoring the need for alternative treatments. Antimicrobial peptides (AMPs) have shown promise in this regard, with maximin 1 being a cationic, amphipathic AMP possessing antibacterial, antifungal, and antiviral activities with low hemolytic activity. In this study, we used molecular dynamics simulation to investigate the molecular basis for membrane selectivity of Maximin 1.

Computational studies on potential small molecule inhibitors of pteridine reductase 1.

Leishmaniasis is a neglected tropical disease of major public health concern. Challenges with current therapeutics have led to the exploration of plant medicine for potential antileishmanial agents. Despite the promising activity of some antileishmanial natural products, their protein targets have not been explored.