The Liver in Hemophagocytic Lymphohistiocytosis: Not an Innocent Bystander.

Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystemic hyperinflammatory disease commonly associated with hepatic dysfunction. Liver injury is mediated by unchecked antigen presentation, hypercytokinemia, dysregulated cytotoxicity by natural killer and CD8 T cells, and disruption of intrinsic hepatic metabolic pathways. Over the past decade, there have been significant advances in diagnostics and expansion in therapeutic armamentarium for this disorder allowing for improved morbidity and mortality.

Isolated Terminal Ileitis in Children.

Isolated terminal ileitis in adults is a well described entity that rarely progresses to Crohn disease (CD), and pediatric literature on this topic is very limited. We describe the prevalence, clinical, endoscopic, histologic, and radiological features, along with long-term outcome of isolated terminal ileitis in our institution. We reviewed charts of 956 children who underwent colonoscopy from 2013 to 2017.

Hepatitis B and C in Children.

Hepatitis B and hepatitis C are a global burden and underscore the impact of preventable acute and chronic diseases on personal as well as population level health. Caring for pediatric patients with hepatitis B and C requires a deep understanding of the pathophysiology of viral processes. Insight into the epidemiology, transmission, and surveillance of these infections is critical to prevention and therapy.

Atomic Clock Measurements of Quantum Scattering Phase Shifts Spanning Feshbach Resonances at Ultralow Fields.

We use an atomic fountain clock to measure quantum scattering phase shifts precisely through a series of narrow, low-field Feshbach resonances at average collision energies below 1  μK. Our low spread in collision energy yields phase variations of order ±π/2 for target atoms in several F, m_{F} states. We compare them to a theoretical model and establish the accuracy of the measurements and the theoretical uncertainties from the fitted potential.

Accelerated follicle depletion in vitro and in vivo in Sprague-Dawley rats using the combination of 4-vinylcyclohexene diepoxide and triptolide.

Rodent pests cause major damage to the world's agricultural crops and food stores. Rodenticides used since World War II did not lead to sustained reduction of rodent populations, and so fertility control is becoming attractive because rats reproduce with great efficiency. Chemical acceleration of ovarian failure via oral dosing also would improve management of rat pest populations.

Direct observation of resonant scattering phase shifts and their energy dependence.

We scan the collision energy of two clouds of cesium atoms between 12 and 50  μK in an atomic fountain clock. By directly detecting the difference of s-wave scattering phase shifts, we observe a rapid variation of a scattering phase shift through a series of Feshbach resonances. At the energies we use, resonances that overlap at threshold become resolved.