Publications by authors named "Aaron Abraham"
Hypertrophic cardiomyopathy (HCM) is a hereditary cardiovascular condition marked by heart muscle thickening, fibrosis, and myocardial disorders. It is often inherited in an autosomal dominant pattern. Symptoms include dyspnea, fatigue, palpitations, dizziness, syncope, and an increased risk of sudden cardiac death (SCD).
View Article and Find Full Text PDFArticle Synopsis
- - Long QT syndrome (LQTS) is a heart condition caused by prolonged electrical repolarization, which can lead to serious arrhythmias, and is identified through an extended QT interval on an electrocardiogram (ECG).
- - Treatment typically involves beta-blockers for higher-risk patients, while lifestyle changes and regular monitoring apply to intermediate and low-risk patients; implantable cardioverter-defibrillators (ICDs) may be necessary for those with severe cases.
- - Despite advancements in AI aiding diagnosis and management, significant gaps in understanding LQTS remain, indicating a need for further research on risk stratification and personalized treatment strategies.
Article Synopsis
- Brugada syndrome (BrS) is an inherited heart condition that leads to abnormal heart rhythms and an increased risk of sudden cardiac death, primarily caused by mutations in the SCN5A gene.
- Diagnosis can be tricky due to its hidden ECG signs and symptoms that resemble other heart disorders, mostly affecting young, healthy males.
- Treatment mainly involves managing symptoms and preventing sudden death, primarily through implantable cardioverter-defibrillators (ICDs), with recent advancements in catheter ablation and specific medications like quinidine showing promise despite challenges in long-term management and availability.
Objective: Our research objective is to work with leaders of houses of worship in the local community to assess options for the physically reopening of places of worship.
Method: This study consists of two parts. The first part consists of working with a leader of a house of worship to formulate a decision process based on the priorities of the organization and its physical size and population.
The enzyme Poly(ADP-ribose) polymerase 1 (PARP1) plays a very important role in the DNA damage response, but its role in numerous aspects is not fully understood. We recently showed that in the absence of DNA damage, PARP1 regulates the expression of the chromatin-modifying enzyme EZH2. Work from other groups has shown that EZH2 participates in the DNA damage response.
View Article and Find Full Text PDF