Nanoporous Graphene with Encapsulated Multicomponent Carbide as High-Performance Binder-Free Lithium-Ion Battery Anodes.

Metal carbides are considered attractive lithium-ion battery (LIB) anode materials. Their potential practical application, however, still needs nanostructure optimization to further enhance the Li-storage capacity, especially under large current densities. Herein, a nanoporous structured multi-metal carbide is designed, which is encapsulated in a 3D free-standing nanotubular graphene film (MnNiCoFe-MoC@NG).

Arthroscopic Repair With Side-to-Side Sutures for Full-Thickness Transtendinous Supraspinatus Tears Versus Traditional Tendon to Bone Fixation: Outcomes and Retear Rates at 4-Year Follow-up.

Background: Full-thickness, transtendinous supraspinatus rotator cuff tears involve a significant portion of the remanent tendon attached to the footprint.

Purpose: To compare outcomes and failure rates for arthroscopic side-to-side (STS) suture repair for transtendinous tears versus traditional double-row repair for common tendon-to-bone type tears.

Study Design: Cohort study; Level of evidence, 3.

Unveiling Guyon's Canal: Insights into Clinical Anatomy, Pathology, and Imaging.

Guyon's canal, or the ulnar tunnel, is a critical anatomical structure at the wrist that houses the ulnar nerve and artery, making it susceptible to various pathological conditions. Pathologies affecting this canal include traumatic injuries, compressive neuropathies like ulnar tunnel syndrome, and space-occupying lesions such as ganglion cysts. Ulnar tunnel syndrome, characterised by numbness, tingling, and weakness in the ulnar nerve distribution, is a prevalent condition that can severely impair hand function.

Continuous quality improvement for prehospital STEMI improved triage rates and achievement of gold standard < 90-min EMS-to-balloon time.

Background: ST-elevation myocardial infarction (STEMI) is a type of myocardial infarction caused by a buildup of plaque or clot in the coronary arteries. There are approximately 750,000 STEMI cases each year in the United States. The American Heart Association's Mission Lifeline initiative aimed to optimize prehospital emergency medical services (EMS) and enhance STEMI triage rates through improved standardized protocol.

NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 2.2025.

The NCCN Guidelines for Myelodysplastic Syndromes (MDS) provide recommendations for the evaluation, diagnosis, and comprehensive care of patients with MDS based on a review of recent clinical evidence that has led to important advances in treatment or has yielded new information on biologic factors that may have prognostic significance in MDS. The multidisciplinary panel of MDS experts is convened at least on an annual basis. During the annual meeting, the panel evaluates new and emerging data to inform their recommendations.

The neurorepellent SLIT2 inhibits LPS-induced proinflammatory signaling in macrophages.

Macrophages are important mediators of immune responses with critical roles in the recognition and clearance of pathogens, as well as in the resolution of inflammation and wound healing. The neuronal guidance cue SLIT2 has been widely studied for its effects on immune cell functions, most notably directional cell migration. Recently, SLIT2 has been shown to directly enhance bacterial killing by macrophages, but the effects of SLIT2 on inflammatory activation of macrophages are less known.

Left ventricular-arterial coupling and mortality in the cardiac intensive care unit.

Background: Left ventricular (LV) ventricular-arterial coupling (VAC) refers to the ratio of afterload (effective arterial elastance) to contractility (end-systolic elastance) as an integrated marker of cardiac performance. We sought to determine whether the echocardiographic VAC ratio, defined using the ratio of LV end-systolic volume (LVESV) to stroke volume (SV), predicted mortality in the cardiac intensive care unit (CICU).

Methods: Mayo Clinic CICU patients from 2007 and 2018 were included.

Green Synthesis and Characterization of Silver Nanoparticles from Leaf Extract: Evaluation of Their Antioxidant, Anti-Inflammatory, Antibacterial, and Antibiofilm Efficacies.

The use of metal nanoparticles is gaining popularity owing to their low cost and high efficacy. We focused on green synthesis of silver nanoparticles (AgNPs) using (Tc) leaf extracts. The structural characteristics of Tc nanoparticles (TcAgNPs) were determined using several advanced techniques.

Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans.

Background: Amniotic fluid (AF) plays a key role in fetal development, yet the evolving composition of AF and its effects on hemostasis and thrombosis are poorly understood.

Objectives: To characterize the procoagulant properties of AF as a function of gestation in humans and nonhuman primates.

Methods: We analyzed the proteomes, lipidomes, and procoagulant properties of AF obtained by amniocentesis from rhesus macaque and human pregnancies at gestational age-matched time points.

Low-cost and automated magnetic bead-based DNA data writing digital microfluidics.

The rapid growth in data generation presents a significant challenge for conventional storage technologies. DNA storage has emerged as a promising solution, offering substantially greater storage density and durability. However, the current DNA data writing process is costly and labor-intensive, hindering the commercialization of DNA data storage.

Palmitic acid alters enhancers/super-enhancers near inflammatory and efferocytosis-associated genes in human monocytes.

Free fatty acids like palmitic acid (PA) are elevated in obesity and diabetes and dysregulate monocyte and macrophage functions, contributing to enhanced inflammation in these cardiometabolic diseases. Epigenetic mechanisms regulating enhancer functions play key roles in inflammatory gene expression, but their role in PA-induced monocyte/macrophage dysfunction is unknown. We found that PA treatment altered the epigenetic landscape of enhancers and super-enhancers (SEs) in human monocytes.

Spiral twisting of distal (V4) vertebral arteries in an asymptomatic female and its embryological basis.

Intracranial vessels develop early in embryonic life through mutual interaction and integration of aortic arches giving the carotid arteries and intrinsic longitudinal neural system forming the posterior circulation. Due to the relatively short time and faster pace of completion of development, minor absent/persistent segments may give rise to either asymptomatic anatomical variants or hemodynamically significant changes. Intracranial vessels - both anterior carotid and posterior vertebrobasilar systems - are known to have many common anatomical variations like hypoplastic segments (A1 or P1 segments of anterior or posterior cerebral arteries) and persistent carotid-vertebrobasilar anastomotic channels.

Assessment of Quality of Life in Chronic Otitis Media After Type 1 Tympanoplasty - An Observational Study.

This study is aimed to assess the outcome of Type-1Tympanoplasty in patients of Chronic Otitis Media (COM)- mucosal type and document the associated hearing gain and correlate it with the improvement in Quality of life (QOL) using COMOT (Chronic Otitis Media Outcome Test) 15 scoring. A hospital based prospective study was carried out in a tertiary care centre on 80 patients of mucosal type of COM. Patients were given COMOT 15 questionnaire to score the symptoms and pure tone audiometry (PTA) was done to assess hearing level.

Self-reported history of head injury is associated with cognitive impulsivity on a delay discounting task.

Background: Head injuries are a major health care concern that can produce many long lasting cognitive, mental, and physical problems. An emerging literature indicates increased impulsivity in patients with a history of traumatic brain injury (TBI). In a recent study, Veterans with clinically-assessed history of mild TBI had increased cognitive, but not motor, impulsivity.

Echocardiographic Assessment in Various Obesity Phenotypes: A Cross-Sectional Study.

Background Obesity is a risk factor for metabolic syndrome, which is a combination of metabolic abnormalities leading to development of cardiovascular abnormalities. Based on factors such as body mass index and metabolic syndrome, specific phenotypes for obesity have been established. These include metabolically healthy obese (MHO), metabolically unhealthy non-obese (MUNO), metabolically unhealthy obese (MUO), and metabolically healthy non-obese (MHNO).

Index-Based selection of Chickpea (Cicer arietinum L.) genotypes for enhanced drought tolerance.

Chickpea, a protein-rich legume grown primarily in tropical and subtropical regions, faces significant challenges due to drought stress. A field study was conducted over two years (2020-21 and 2021-22) aimed to identify chickpea genotypes that are tolerant to drought. The study involved 25 chickpea genotypes subjected to irrigated (control) and water stress (drought) conditions and the experiment was arranged in a split-plot design.

Changes in primary care encounter rates during the veteran health administration's electronic health record transition.

Background: Electronic health record (EHR) transitions can cause major disruptions in the provision of primary care services. Veteran Health Administration (VHA), one of the largest integrated healthcare systems, underwent a major EHR transition at two sites. To date, there is limited data on the experience of primary care service lines at EHR transition sites.

Genomic insights into Mediterranean pepper diversity using ddRADSeq.

This work investigated the genetic diversity and population structure of 99 pepper lines (Capsicum annuum L.), acclimated to Mediterranean climate conditions, using double-digest restriction site-associated DNA sequencing (ddRADSeq). The aims were to understand the genetic relationships among these lines, correlate genetic clusters with botanical classifications, and provide insights into pepper domestication in the region.

Photoconductivity Switching in Semiconducting Two-Dimensional Crystals via Molecular Tetris.

Two-dimensional organic materials are mainly constructed by using orthogonal anisotropic connectivity of covalent bonding and π-π stacking. The noncovalent connectivity between building blocks is presumed to be too delicate to stabilize the two-dimensional (2D) layers. Contrary to this assumption, we constructed graphite-like 2D layered material by utilizing pure noncovalent connectivity, i.

Accuracy and Reliability of Oral Exfoliative Cytology in Age Estimation: An Observational Study.

Aim And Objectives: Age and gender identification are critical in forensic investigations, especially for unidentified human bodies. This study explores differences in nuclear size, nuclear area, and nuclear-cytoplasmic ratio between healthy individuals and those with physiological or pathological conditions, aiming to understand how these variations may influence age estimation.

Materials And Methods: Following ethical clearance, the study was conducted on 80 participants aged 20-35 years, who were divided into four groups of 20 each, Group 1: Healthy individuals; Group 2: Individuals with physiological variations; Group 3: Individuals with pathological variations; and Group 4: Individuals with acquired conditions.

After Effects of Radiation on the Caries Status of Head and Neck Cancer Patients - A Six-Month Clinical Trial.

Background: Head and neck cancer patients undergoing radiation therapy (RT) are at an increased risk of dental caries due to radiation-induced damage to salivary glands. This study aimed to compare the effectiveness of three interventions-virgin coconut oil (VCO), casein phosphopeptide-amorphous calcium phosphate tooth mousse (TM), and amine fluoride mouthwash (MW)-in preventing caries among head and neck cancer patients' post-radiation therapy.

Methods: A total of 102 head and neck cancer patients undergoing RT were enrolled.

Integrated Pediatric Intensive Care and Hematopoietic Stem Cell Transplantation Service Improves The Peri-Transplant Survival In Children.

Background: Peri-transplant is a critical period which is associated with a myriad of complications that require pediatric intensive care unit (PICU) referral. PICU outcomes have been historically poor post-hematopoietic stem cell transplantation (HSCT), especially when associated with inotrope support, invasive ventilation, and renal replacement therapy. The study aimed to assess the outcomes of PICU referral in children undergoing HSCT.

Hearing loss characteristics and cerumen management efficacy in low-income South African communities: a cross-sectional study.

Aim: To describe the prevalence and characteristics of hearing loss in a self-referred adult cohort in low-income South African communities and to evaluate the effectiveness of a cerumen management protocol within a community-based service setting.

Background: Hearing loss affects 1.5 billion people globally, with a disproportionate impact on individuals in low- and middle-income countries (LMICs) and the elderly, often attributed to age-related factors and cerumen impaction.

Chronic Adaptations of the Ulnar Nerve in Professional Baseball Pitchers: Ulnar Nerve Adaptations in Pitchers.

Context: Screening programs to identify negative ulnar nerve adaptations in throwing athletes can help minimize injury risk and individualize treatment programs prior to the onset of symptoms. However, it is currently unclear how the ulnar nerve structurally adapts chronically in professional baseball pitchers. Objective: To compare ulnar nerve ultrasound structural characteristics between the throwing (dominant) and non-throwing control (non-dominant) elbows in professional pitchers, with a secondary purpose of comparing ultrasound structural characteristics between subluxating and non-subluxating ulnar nerves.