Publications by authors named "Aaren Vedangi"
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and buttocks. The pathogenesis of HS is not fully understood, but considering the key role played by the biological clock in the control of immune/inflammatory processes the derangement of circadian and ultradian pathways could be hypothesized.
Methods: We analyzed genome-wide DNA methylation patterns in peripheral blood from 24 HS cases and 24 controls using the Infinium HumanMethylation450 BeadChip array (Illumina), followed by bioinformatics and statistical analyses.
Article Synopsis
- Scientists are studying a skin condition called Hidradenitis suppurativa (HS) and how certain genes, known as long noncoding RNAs (lncRNAs), change in people with this condition.
- They looked at the blood of 24 patients with HS and compared it to healthy people to see how the lncRNAs were different.
- They found that some lncRNAs had unusual patterns that might affect important body processes like inflammation and healing, which could help in creating better treatments for HS.
Hidradenitis suppurativa associated telomere-methylome dysregulations in blood.
J Eur Acad Dermatol Venereol
February 2024
Background: Hidradenitis suppurativa (HS) is a chronic debilitating disease with a significant burden of both organic and psychological comorbidities. It has been shown that certain telomere-related genes (TRGs) affect a wide range of diseases, including HS and its associated comorbidities, but their exact role in HS pathogenesis is still unknown.
Objectives: To determine whether TRG methylomes can be used as biomarkers in HS.
Background: Hidradenitis suppurativa (HS) is a chronic, systemic, inflammatory skin condition with elusive pathogenesis that affects therapeutic intervention directly.
Objective: To characterize epigenetic variations in cytokines genes contributing to HS.
Methods: Epigenome-wide DNA methylation profiling with the Illumina Epic array was performed on blood DNA samples from 24 HS patients and 24 age- and sex-matched controls to explore DNA methylation changes in cytokine genes.