Publications by authors named "Aarathy Ravi Sundar Jose Geetha"
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is called homeostasis. Here we demonstrate that JAK-STAT signaling, beyond its role in immune responses, is a major regulator of immune cell homeostasis.
View Article and Find Full Text PDFArticle Synopsis
- Type I interferons (IFN-I, including IFNβ) and IFNγ exhibit both overlapping and unique immune functions, but their differences in transcriptional responses become clear over time rather than immediately.
- Research indicates that the variations in the transcriptome between the two interferon types are influenced by the ISGF3 complex and the IRF1 transcription factor, leading to a diverse array of nuclear protein interactions.
- The study highlights how these transcription factors impact enhancer activation and chromatin accessibility at interferon-stimulated genes, as well as variations in the regulation of RNA polymerase II pausing at gene start sites, contributing to the distinct immunological roles of IFN-I and IFNγ.
Engagement of macrophages in innate immune responses is directed by type I and type II interferons (IFN-I and IFN-γ, respectively). IFN triggers drastic changes in cellular transcriptomes, executed by JAK-STAT signal transduction and the transcriptional control of interferon-stimulated genes (ISG) by STAT transcription factors. Here, we study the immediate-early nuclear response to IFN-I and IFN-γ in murine macrophages.
View Article and Find Full Text PDF