Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling.

Intestinal microbes impact the health of the intestine and organs distal to the gut. is a human intestinal microbe that promotes normal gut transit, the anti-inflammatory immune system, wound healing, normal social behavior in mice, and prevents bone reabsorption. Oxytocin impacts these functions and oxytocin signaling is required for -mediated wound healing and social behavior; however, the events in the gut leading to oxytocin stimulation and beneficial effects are unknown.

Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling.

Intestinal microbes impact the health of the intestine and organs distal to the gut. is a human intestinal microbe that promotes normal gut transit , the anti-inflammatory immune system , wound healing , normal social behavior in mice , and prevents bone reabsorption . Each of these functions is impacted by oxytocin , and oxytocin signaling is required for mediated wound healing and social behavior ; however, the initiating events in the gut that lead to oxytocin stimulation and related beneficial functions remain unknown.