Clinical Interpretation of Detection of IgM Anti- Antibody in the Absence of IgG and ; a Diagnostic Challenge for Clinicians.

Non-specific and often misleading clinical presentation of active brucellosis has made it a diagnostic puzzle for treating physicians. Clinicians rely greatly on the detection of IgG and IgM anti- antibodies by ELISA. Different patterns of positivity have been observed for IgG and IgM anti- antibodies in different cases, which further increases the risk of an erroneous diagnosis.

Parameter estimation of qualitative biological regulatory networks on high performance computing hardware.

Background: Biological Regulatory Networks (BRNs) are responsible for developmental and maintenance related functions in organisms. These functions are implemented by the dynamics of BRNs and are sensitive to regulations enforced by specific activators and inhibitors. The logical modeling formalism by René Thomas incorporates this sensitivity with a set of logical parameters modulated by available regulators, varying with time.

Skin Prick Test Reactivity to Common Aeroallergens among Allergic Rhinitis Patients.

Objective: To identify the common aeroallergens causing allergy symptoms among the allergic rhinitis patients.

Study Design: Cross-sectional study.

Place And Duration Of Study: Department of Immunology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from January to July 2016.

Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression.

The alteration of glucose metabolism, through increased uptake of glucose and glutamine addiction, is essential to cancer cell growth and invasion. Increased flux of glucose through the Hexosamine Biosynthetic Pathway (HBP) drives increased cellular O-GlcNAcylation (hyper-O-GlcNAcylation) and contributes to cancer progression by regulating key oncogenes. However, the association between hyper-O-GlcNAcylation and activation of these oncogenes remains poorly characterized.