Relation of tranexamic acid therapy to length of stay in the hip fracture population.

Tranexamic acid (TXA) is a medication that is routinely used to minimize blood loss during surgery. There is minimal literature evaluating the effects of TXA in hip fractures in regards to length of stay, readmission rates, and location of discharge. This study included adult patients who were admitted for hip fracture that required surgery over a 22-month period (May 2017-February 2019).

Total Hip Arthroplasty in Patients With Severe Chronic Pubic Diastasis.

Background: Total hip arthroplasty (THA) in patients with severe chronic pubic diastasis from either congenital or acquired causes presents an exceptionally difficult challenge that has rarely been addressed in the arthroplasty literature. The purpose of this paper is to present a series of THAs in patients with severe chronic pubic diastasis, asking the following research questions: (1) What is the survivorship and clinical outcomes after THA in patients with severe chronic pubic diastasis? And (2) What is the rate of complications after THA surgery in this challenging patient population? We additionally describe our algorithm for preoperative planning and rationale for surgical technique and implant position.

Material And Methods: We retrospectively queried the prospective arthroplasty database of 2 high-volume referral centers, yielding 6 THA in 4 patients with severe chronic pubic diastasis (minimum 8 cm) with a mean follow-up of 2.

Surgical automation reduces operating time while maintaining accuracy for direct anterior total hip arthroplasty.

Objective: Investigate the efficiency/accuracy of surgical automation versus manual component implantation in DA THA.

Methods: Retrospective review of 111 hips: 51 hips via automation and 60 hips via manual technique for DA THA.

Results: OR time averaged 8 min faster in the Automated group, compared to Manual group ( = 0.

Financial impact of removal of total knee arthroplasty from the inpatient-only list for a physician-owned BPCI program.

Objective: Assessing financial effects of removal of TKA from CMS inpatient-only list on physician-owned bundles.

Methods: We determined whether Medicare TKAs remained inpatient, versus changed to observational. We used CMS data to determine savings.

Prospects of modeling poststroke epileptogenesis.

This Review describes the current status of poststroke epilepsy (PSE) with an emphasis on poststroke epileptogenesis modeling for testing new therapeutic agents. Stroke is a leading cause of epilepsy in an aging population. Late-onset "epileptic" seizures have been reported in up to 30% cases after stroke.

Validation of an HPV16-mediated carcinogenesis mouse model.

Background/aim: Human papillomavirus Type 16 (HPV16) infection is a necessary but alone insufficient cause of invasive cervical cancer (ICC) and likely causes other genital cancers. Individual genetic variability influences the natural history of the neoplasm. Developing a variety of animal models to investigate HPV16-mediated carcinogenesis is important to Phase 1 trials for human cancer treatments.