Experimental and numerical analysis of pGFRP and wood cross-arm in latticed tower: a comprehensive study of mechanical deformation and flexural creep.

The adoption of pultruded glass fibre-reinforced polymer (pGFRP) composites as a substitute for traditional wooden cross-arms in high transmission towers represents a relatively novel approach. These materials were selected for their high strength-to-weight ratio and lightweight properties. Despite various studies focusing on structures improvement, there still have a significant gap in understanding the deformation characteristics of full-scale cross-arms under actual operational loads.

Housing Temperature Influences Metabolic Phenotype of Heart Failure with Preserved Ejection Fraction in J vs N Strain C57BL/6 Mice.

Preclinical heart failure studies rely heavily on mouse models despite their higher metabolic and heart rates compared to humans. This study examines how mouse strain (C57BL/6J vs. C57BL/6N) and housing temperature (23°C vs.

Experiences of fasting during Ramadan in British Muslims: Psychological, social and health behaviours.

Ramadan is a month-long religious festival observed by Muslim worldwide, characterised by intermittent fasting. This qualitative study addressed the need to understand how fasting is experienced by Muslims residing in Western cultures, aiming to inform policies that create a more supportive environment. Practicing Muslims, both men and women, were recruited in the North of England in the United Kingdom (UK).

Biomarkers.

Background: Data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial (NCT02008357), including cognitively unimpaired participants with brain amyloid pathology on florbetapir F 18, demonstrates that levels of plasma P-tau217, as detected by an electrochemiluminescence (ECL) immunoassay, is strong predictor of elevated cerebral amyloid on florbetapir PET in cognitively unimpaired individuals. Here we compare plasma P-tau217 measures over 12 weeks using a P-tau217 ECL immunoassay.

Method: A4 trial placebo-group participants who had their first baseline and first post-baseline plasma P-tau217 samples collected within 175 days of each other were included in these analyses.

Computer-Aided Diagnosis in Spontaneous Abortion: A Histopathology Dataset and Benchmark for Products of Conception.

Spontaneous abortion, commonly known as miscarriage, is a significant concern during early pregnancy. Histopathological examination of tissue samples is a widely used method to diagnose and classify tissue phenotypes found in products of conception (POC) after spontaneous abortion. Histopathological examination is subjective and dependent on the skill and experience of the examiner.

Fahr's Syndrome With Hypoparathyroidism in a Patient With Schizophrenia and Iron Deficiency Anemia: A Case Report.

Fahr's syndrome is a rare neurological disorder that shows up as calcium deposits in the brain, affecting motor control and cognitive functions. In this case report, a 45-year-old woman with schizophrenia was diagnosed with Fahr's syndrome, which can be challenging to diagnose due to coexisting neurological comorbidity.

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) displays a high degree of spatial subtype heterogeneity and co-existence, linked to a diverse microenvironment and worse clinical outcome. However, the underlying mechanisms remain unclear. Here, by combining preclinical models, multi-center clinical, transcriptomic, proteomic, and patient bioimaging data, we identify an interplay between neoplastic intrinsic AP1 transcription factor dichotomy and extrinsic macrophages driving subtype co-existence and an immunosuppressive microenvironment.

Impact of CaNa2EDTA fortification on growth, antioxidant activity and stress-related gene expression in tilapia (Oreochromis niloticus) at different stocking densities paradigms.

Increasing aquaculture production requires high-density farming, which induces stress, necessitating supplements to mitigate its effects and ensure fish health. The aim of this study was to examine how CaNa2EDTA (EDTA) affects the growth, immune response and antioxidant activity in Nile tilapia (Oreochromis niloticus). The fish were raised at three different stocking densities: low (LD = 2.

Antibiofilm and Antiquorum Sensing Potential of Pheretima posthum.

Antibiotic resistance is a world wide problem mainly in developing countries. In this work, coelomic fluid (PCF) and paste (PBP) of Pheretima posthuma was assessed for its potential as antibiofilm and anti-quorum sensing (QS) agent against pathogenic bacterial biofilms. PCF and PBP were extracted and biofilm formation time kinetics was examined using crystal violet staining method by utilizing four bacterial isolates in bispecies biofilm (06 combinations; MH5-MH10) and multi species biofilms (05 combinations; MH11-MH15).

Biallelic Variant in the AGXT Gene in a Family Segregating Primary Hyperoxaluria; Accurate Genetic Diagnosis and Carrier Detection.

Aim: Autosomal recessive primary hyperoxalurias (PH) are genetic disorders characterised by elevated oxalate production. Mutations in genes involved in glycoxylate metabolism are the underlying cause of PH. Type 1 PH (PH1) results in malfunctioning of alanine-glyoxylate aminotransferase enzymes of liver due to a change in the genetic sequence of alanine-glyoxylate aminotransferase (AGXT) gene.

Can Grading of Mild Cardiac Allograft Vasculopathy be Further Refined? An angiographic and physiologic assessment of heart transplant recipients with ISHLT CAV 1.

Background: Cardiac allograft vasculopathy (CAV) results in impaired blood flow in both epicardial vessels and the microvasculature and is a leading cause of poor outcomes in heart transplant (HT) recipients. Most patients have mild (ISHLT CAV 1) disease. This study examined outcomes amongst those with ISHLT CAV 1 and investigated the value of physiologic assessment via cardiac positron emission tomography/computed tomography (PET/CT) for added risk stratification.

Variation of Neck Length on Anterior and Posterior Aspect of Femur in Bangladeshi People.

The regional variation of the femur bone is influenced by sex, stature geographical area and heredity, as the environment plays an important role in the developmental process. This cross-sectional descriptive purposive study was done on 150 (64 right and 86 left) fully ossified dry human femur of Bangladeshi people to find out the variation of neck length on anterior and posterior aspect. Sample was collected in the Department of Anatomy, Mymensingh Medical College, Bangladesh from January 2019 to December 2019.

Broccoli () leaves exhibit significant antidiabetic potential in alloxan-induced diabetic rats: the putative role of ABC vacuolar transporter for accumulation of Quercetin and Kaempferol.

Background: The global prevalence of diabetes among adults over 18 years of age is expected to increase from 10.5% to 12.2% (between 2021 and 2045).

Csec-net: a novel deep features fusion and entropy-controlled firefly feature selection framework for leukemia classification.

Leukemia, a life-threatening form of cancer, poses a significant global health challenge affecting individuals of all age groups, including both children and adults. Currently, the diagnostic process relies on manual analysis of microscopic images of blood samples. In recent years, machine learning employing deep learning approaches has emerged as cutting-edge solutions for image classification problems.

A ridge-loaded staggered double-vane slow wave structure for terahertz radiation sources.

A ridge-loaded staggered double-vane slow-wave structure is proposed for terahertz radiation sources employing a sheet electron beam. This slow-wave structure has the advantages of enhanced electric field and energy density distribution and improved interaction impedance in the beam-wave interaction region. High-frequency characteristics are investigated for the proposed slow wave structure and compared with those of the staggered double-vane slow wave structure.

Development and structural comparison of alkaline and organosolv coconut husks lignin as an eco-friendly lignin-phenol-glyoxal (LPG) wood adhesives.

The development of eco-friendly wood adhesives have gained more interest among adhesives industries due to the concerns about using carcinogenic formaldehyde and petroleum-based phenol in commercially available adhesives. Therefore, many studies have been done by using lignin to partially replace phenol and completely substitute formaldehyde with non-toxic glyoxal in a wood adhesive formulation. This study focused on using different percentages of lignin substitution (10 %, 30 % and 50 wt%) of alkaline and organosolv coconut husk lignin into soda lignin-phenol-glyoxal (SLPG), Kraft lignin-phenol-glyoxal (KLPG) and organosolv lignin-phenol-glyoxal (OLPG) adhesives.

Endoscopic third ventriculostomy with or without choroid plexus cauterization for preventing shunt dependence in pediatric hydrocephalus: preliminary results of a prospective clinical case series in a lower-middle-income country (Egypt).

Purpose: Pediatric hydrocephalus imposes a significant clinical and financial burden in developing countries. Traditional treatment by ventricular shunting in this setting suffers a high rate of shunt infection and malfunction. This study aims at assessing the efficacy and safety of endoscopic third ventriculostomy (ETV), either alone or combined with choroid plexus cauterization (CPC), for preventing shunt dependence in pediatric hydrocephalus within a healthcare setting of a tertiary hospital in Egypt.

Stunting Super App as an Effort Toward Stunting Management in Indonesia: Delphi and Pilot Study.

Background: Currently, 30 million children are experiencing acute malnutrition, and 8 million children are severely underweight.

Objective: This study aimed to develop a stunting super app, a one-stop app designed to prevent and manage stunting in Indonesia.

Methods: This study consisted of three stages.

Immunological Responses, Expression of Immune-Related Genes, and Disease Resistance of Rainbow Trout () Fed Diets Supplied with Capsicum () Oleoresin.

A 45-day feeding study was carried out to assess the immune-stimulatory effects of capsicum oleoresin when added to rainbow trout diets. A total of 450 fish (mean weight: 155.20 ± 1.

Calcitriol ameliorates cisplatin-induced hepatorenal toxicity via regulation of Nrf2-Mrp2/p38 MAPK signaling in mice.

Despite being one of the most frequently used chemotherapy agents, cisplatin exhibits substantial hepatorenal injury by triggering oxidative stress, inflammation, and apoptosis pathways. The current investigation studied the possible protective effects of calcitriol on cisplatin-induced hepatorenal toxicity. Mice were divided randomly as follows: control group, calcitriol group (received calcitriol 5 µg/kg, p.

Trimethylamine N-oxide in cardiovascular disease: Pathophysiology and the potential role of statins.

Cardiovascular diseases are one of the leading causes of mortality and morbidity worldwide, with the total number of cases increasing to 523 million in 2019. Despite the advent of new drugs, cardiovascular mortality has increased at an alarming rate of 53.7 % from 12.

Effect of traffic volumes on polycyclic aromatic hydrocarbons of particulate matter: A comparative study from urban and rural areas in Malaysia.

Motor vehicles emit most Malaysian PAHs in particulate matter of 2.5 μm (PM2.5-bound PAHs).

Number of macula optical coherence tomography scans needed to detect glaucoma progression.

Background: To evaluate the impact of testing frequency on the time required to detect statistically significant glaucoma progression for ganglion cell complex (GCC) with optical coherence tomography (OCT).

Materials And Methods: From multicentre glaucoma registries, 332 eyes of 201 glaucoma patients were enrolled over an average of 4.4 years.

Elevated Donor-Derived Cell-Free DNA Levels Are Associated With Reduced Myocardial Blood Flow but Not Angiographic Cardiac Allograft Vasculopathy: The EVIDENT Study.

Background: Cardiac allograft vasculopathy (CAV) leads to impaired myocardial blood flow (MBF), increasing the risk of cardiovascular death or retransplant among heart transplantation (HT) recipients. Data on elevation in donor-derived cell-free DNA (dd-cfDNA) and CAV in the absence of rejection are mixed. We sought to test the hypothesis that CAV with reduced MBF (RMBF) is associated with elevated dd-cfDNA.