Retention of new AEDs in institutionalized intellectually disabled patients with epilepsy.

Purpose: To assess the long-term usefulness of 'new anti-epileptic drugs (AEDs)' (lamotrigine, topiramate, levetiracetam, gabapentin and pregabalin) in institutionalized intellectually disabled patients. Information from RCTs is lacking in this population with severe intellectual and behavioural disabilities.

Methods: Retrospective study.

HLA-B*0702 antibody epitopes are affected indirectly by distant antigen residues.

We examine the effect of mutations in the HLA-B*0702 alpha 1 domain on the binding of several well-characterized monoclonal antibodies. BB7.1 recognizes the alpha-helix, with a special requirement for residue 67.